CPSF7 and MIR19A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		CPSF7	MIR19A
Description		cleavage and polyadenylation specific factor 7	microRNA 19a
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Processing MRNA 3'-end Processing Protein Tetramerization Protein Heterotetramerization MRNA Alternative Polyadenylation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Fibroblast Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization B Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To Bacterial Lipopeptide Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Regulation Of Cardiac Conduction Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Matrix Metallopeptidase Secretion
Pathways		mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS
Interacting Genes		106 interacting genes: ALG13 APBB1 ARMC7 ATXN1 BAG4 BCAS2 CATSPER1 CD2BP2 CEBPA CEP55 CFAP206 CLK2 CSNK2A1 CTBP1 CTTN DMRTB1 DRC4 DVL2 EIF4ENIF1 EPM2AIP1 ESS2 EWSR1 EXOSC1 EXOSC5 EXOSC8 GCC1 GRB2 GTSE1 GUCD1 HINT1 HNRNPF ITCH KHDRBS3 KRT31 LENG1 LENG8 LNX1 LSM5 MAGOH MAILR MIR1-1 MIR1-2 MIR10B MIR128-2 MIR141 MIR155 MIR16-1 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR25 MIR29C MIR34B MIR7-1 MIR9-2 MIR93 MIRLET7B MREG NCK2 NIP7 NUDT21 NXF1 OGT PATZ1 PID1 PQBP1 PRKAA2 PRMT2 PRPF6 QKI RBFOX2 RBM10 RBM7 RBPMS RUNX1T1 SEC23B SF1 SF3B4 SFPQ SLAIN1 SMAD3 SNRNP25 SNRPC SNRPF SNW1 SNX18 SORBS3 SPG21 SRPK2 SRSF1 SRSF4 SUMO2 SUPT5H TFIP11 TLE5 TNS2 TUT4 TXNL4A U2AF2 UNKL WBP4 WWOX YTHDF1 YTHDF3	99 interacting genes: AGO2 AIMP2 APOBEC3B ATXN2L C1QBP CELF1 CELF2 CPSF1 CPSF2 CPSF3 CPSF4 CPSF6 CPSF7 CRTAP CSTF2 CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FIP1L1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT21 NUFIP2 P3H1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PURA QARS1 RARS1 RBBP6 RBFOX2 RBM12B RBM14 RBM4 RBMS2 RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 WDR33 WWP1 WWP2 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A
Entrez ID		79869	406979
HPRD ID		16906
Ensembl ID		ENSG00000149532	ENSG00000284204
Uniprot IDs		B4DGF8 Q8N684
PDB IDs		3N9U
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulatory NcRNA-mediated Gene Silencing RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Gene Expression RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Gene Expression Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing Positive Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Stability Nucleic Acid Binding Nucleoplasm MRNA Binding Regulation Of RNA Stability MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Regulation Of Primary Metabolic Process Catalytic Step 2 Spliceosome Regulation Of RNA Metabolic Process Regulation Of Translation Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Destabilization Positive Regulation Of Catabolic Process Regulation Of Cardiac Muscle Hypertrophy RNA Destabilization	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Nucleus Macromolecule Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Ribonucleoprotein Complex MRNA Cleavage And Polyadenylation Specificity Factor Complex Nucleoplasm Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulation Of Translation RNA Splicing, Via Transesterification Reactions MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule Spliceosomal Complex MiRNA Binding Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process RNA Stabilization RNA 3'-end Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 3'-end Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability MRNA Stabilization Regulation Of RNA Stability Pre-mRNA Binding Positive Regulation Of Cytoplasmic Translation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Regulation Of Metabolic Process Regulation Of Cytoplasmic Translation
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