CPSF7 and SUPT5H

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		CPSF7	SUPT5H
Description		cleavage and polyadenylation specific factor 7	SPT5 homolog, DSIF elongation factor subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Chromatin Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity
	Biological Process	MRNA Processing MRNA 3'-end Processing Protein Tetramerization Protein Heterotetramerization MRNA Alternative Polyadenylation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway	Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Positive Regulation Of Macroautophagy Regulation Of DNA-templated Transcription Elongation Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs RHOBTB1 GTPase cycle	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS			Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		106 interacting genes: ALG13 APBB1 ARMC7 ATXN1 BAG4 BCAS2 CATSPER1 CD2BP2 CEBPA CEP55 CFAP206 CLK2 CSNK2A1 CTBP1 CTTN DMRTB1 DRC4 DVL2 EIF4ENIF1 EPM2AIP1 ESS2 EWSR1 EXOSC1 EXOSC5 EXOSC8 GCC1 GRB2 GTSE1 GUCD1 HINT1 HNRNPF ITCH KHDRBS3 KRT31 LENG1 LENG8 LNX1 LSM5 MAGOH MAILR MIR1-1 MIR1-2 MIR10B MIR128-2 MIR141 MIR155 MIR16-1 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR25 MIR29C MIR34B MIR7-1 MIR9-2 MIR93 MIRLET7B MREG NCK2 NIP7 NUDT21 NXF1 OGT PATZ1 PID1 PQBP1 PRKAA2 PRMT2 PRPF6 QKI RBFOX2 RBM10 RBM7 RBPMS RUNX1T1 SEC23B SF1 SF3B4 SFPQ SLAIN1 SMAD3 SNRNP25 SNRPC SNRPF SNW1 SNX18 SORBS3 SPG21 SRPK2 SRSF1 SRSF4 SUMO2 SUPT5H TFIP11 TLE5 TNS2 TUT4 TXNL4A U2AF2 UNKL WBP4 WWOX YTHDF1 YTHDF3	51 interacting genes: C9orf78 CCNH CCNT2 CDK7 CDK9 CEP55 CPSF7 CSNK2A1 DBN1 DCAF6 DSCAM EXOSC7 FHL3 GOLGA2 GTF3C1 H2AX HSPB1 HTATSF1 IK IKBKG LMAN2 MAD1L1 MAML3 MNAT1 PCBD1 PGK1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 RPL9 SAP30BP SIK1 SNRNP48 SNX4 SSBP3 SUMO2 SUPT4H1 TERF1 TEX11 TLE5 XRCC5 YBX2 ZBTB3 ZFYVE9 ZNF496 ZNF512B
Entrez ID		79869	6829
HPRD ID		16906	03655
Ensembl ID		ENSG00000149532	ENSG00000196235
Uniprot IDs		B4DGF8 Q8N684	O00267
PDB IDs		3N9U	2DO3 2E6Z 2E70 3H7H 4L1U 5OHO 5OHQ 5OIK 5U98 6EQY 6ER0 6GMH 6GML 6TED 7OKX 7OKY 7OL0 7PKS 7UNC 7UND 7YCX 8A3Y 8P4C 8P4D 8P4E 8P4F 8RBX 8UHA 8UHD 8UHG 8UI0 8UIS 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH2 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulatory NcRNA-mediated Gene Silencing RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Gene Expression RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Gene Expression Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing Positive Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Stability Nucleic Acid Binding Nucleoplasm MRNA Binding Regulation Of RNA Stability MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Regulation Of Primary Metabolic Process Catalytic Step 2 Spliceosome Regulation Of RNA Metabolic Process Regulation Of Translation Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Destabilization Positive Regulation Of Catabolic Process Regulation Of Cardiac Muscle Hypertrophy RNA Destabilization	Nucleus Nucleic Acid Metabolic Process Transcription Factor TFIIK Complex CAK-ERCC2 Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process DNA-templated Transcription Initiation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Nucleobase-containing Compound Biosynthetic Process Regulation Of Gene Expression Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Elongation Protein Peptidyl-prolyl Isomerization Chromosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Chromosome Segregation DNA Metabolic Process Recombinational Repair Protein Localization To Site Of Double-strand Break Protein Binding DNA Recombination Transcription Pausing By RNA Polymerase II Postsynaptic Cytosol Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anoikis Regulation Of Transcription Elongation By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling Macromolecule Biosynthetic Process
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