HYAL3 and DAB1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		HYAL3	DAB1
Gene Name		hyaluronoglucosaminidase 3	Dab, reelin signal transducer, homolog 1 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Lysosome Cytoplasmic Vesicle	Cytosol Brush Border Postsynaptic Density Membrane Neuron Projection Neuronal Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Virus Receptor Activity Hyalurononglucosaminidase Activity Hyaluronoglucuronidase Activity	Phosphatidylinositol 3-kinase Binding
	Biological Process	Carbohydrate Metabolic Process Inflammatory Response Response To Virus Hyaluronan Catabolic Process Response To Antibiotic Cartilage Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To UV-B	Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Midgut Development Adult Walking Behavior Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Cerebral Cortex Radially Oriented Cell Migration Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Radial Glia Guided Migration Of Purkinje Cell Response To Drug Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Lateral Motor Column Neuron Migration
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism CS/DS degradation Hyaluronan uptake and degradation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Hyaluronan metabolism Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS			Bulimia nervosa ( 23568457) Immune reponse to smallpox (secreted IL-10) ( 22610502) Kawasaki disease ( 21221998) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		2 interactors: DAB1 SLC22A2	73 interactors: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CDK6 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM103A1 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MBNL1 MBNL3 MYO6 NAF1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR WDYHV1 ZBTB32 ZC3H10 ZCCHC10 ZNF488
Entrez ID		8372	1600
HPRD ID		04948	04582
Ensembl ID		ENSG00000186792	ENSG00000173406
Uniprot IDs		O43820	O75553
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Cerebellum Structural Organization Lateral Motor Column Neuron Migration Spinal Cord Motor Neuron Migration Radial Glia Guided Migration Of Purkinje Cell Response To Drug Choline Transport Golgi Localization Negative Regulation Of Astrocyte Differentiation Neurotransmitter Biosynthetic Process Histamine Transport Quaternary Ammonium Group Transport Midgut Development Anatomical Structure Arrangement Negative Regulation Of JAK-STAT Cascade Cell Migration In Hindbrain Neurotransmitter Metabolic Process Regulation Of Astrocyte Differentiation Drug Transmembrane Transport Negative Regulation Of Glial Cell Differentiation Ammonium Transmembrane Transport Organic Cation Transport Drug Transport Adult Walking Behavior Cerebellum Morphogenesis Hindbrain Morphogenesis Ventral Spinal Cord Development Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Axonogenesis Ammonium Transport Regulation Of Glial Cell Differentiation Cerebral Cortex Cell Migration Regulation Of JAK-STAT Cascade Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Gliogenesis Body Fluid Secretion Spinal Cord Development Neurotransmitter Secretion Adult Locomotory Behavior Cerebellum Development Negative Regulation Of Neuron Projection Development Cellular Localization Metencephalon Development Digestive Tract Development Regulation Of Neurotransmitter Levels Dendrite Development Negative Regulation Of Cell Projection Organization Digestive System Development	Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Reelin-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Developmental Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Central Nervous System Development Positive Regulation Of Protein Phosphorylation Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Nervous System Development Brain Development Regulation Of Cellular Protein Metabolic Process Gliogenesis Regulation Of Protein Metabolic Process Head Development Anatomical Structure Morphogenesis Response To External Stimulus Cell Surface Receptor Signaling Pathway Forebrain Development System Development Cell Differentiation Movement Of Cell Or Subcellular Component Negative Regulation Of Cellular Metabolic Process Organ Development Wound Healing Immune System Process Layer Formation In Cerebral Cortex Locomotion Neuron Projection Morphogenesis Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Signaling Endocytosis MRNA Processing Neurogenesis Cerebral Cortex Radial Glia Guided Migration
Tagcloud ?		10a 184a1 184b5 3p21 cacna2d2 closest combinated demethylating deoxycytidine deregulated epigenetically flanking hyal1 hyal2 isoform nprl2 rassf1 rassf1a rassf1c sema3b seventeen silenced spearman tmem115 trichostatin trimethylated tusc2 unmethylated zmynd10	assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical
Tagcloud (Difference) ?		10a 184a1 184b5 3p21 cacna2d2 closest combinated demethylating deoxycytidine deregulated epigenetically flanking hyal1 hyal2 isoform nprl2 rassf1 rassf1a rassf1c sema3b seventeen silenced spearman tmem115 trichostatin trimethylated tusc2 unmethylated zmynd10	assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical
Tagcloud (Intersection) ?