HYAL3 and SLC22A2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HYAL3	SLC22A2
Gene Name		hyaluronoglucosaminidase 3	solute carrier family 22 (organic cation transporter), member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Lysosome Cytoplasmic Vesicle	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Hyalurononglucosaminidase Activity Hyaluronoglucuronidase Activity	Steroid Binding Organic Cation Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity
	Biological Process	Carbohydrate Metabolic Process Inflammatory Response Response To Virus Hyaluronan Catabolic Process Response To Antibiotic Cartilage Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To UV-B	Drug Transmembrane Transport Synaptic Transmission Neurotransmitter Secretion Body Fluid Secretion Organic Cation Transport Quaternary Ammonium Group Transport Choline Transport Ion Transmembrane Transport Neurotransmitter Biosynthetic Process Small Molecule Metabolic Process Histamine Transport Transmembrane Transport
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism CS/DS degradation Hyaluronan uptake and degradation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Hyaluronan metabolism Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Na+/Cl- dependent neurotransmitter transporters Neurotransmitter Release Cycle Neurotransmitter Clearance In The Synaptic Cleft Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport Abacavir transport and metabolism Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146) Creatinine levels ( 20383145)
Protein-Protein Interactions		2 interactors: DAB1 SLC22A2	9 interactors: AGO3 CST9L ETV5 EXT2 GTF2B HYAL3 LSM4 POU2AF1 SUMO2
Entrez ID		8372	6582
HPRD ID		04948	04008
Ensembl ID		ENSG00000186792	ENSG00000112499
Uniprot IDs		O43820	O15244
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Cerebellum Structural Organization Lateral Motor Column Neuron Migration Spinal Cord Motor Neuron Migration Radial Glia Guided Migration Of Purkinje Cell Response To Drug Choline Transport Golgi Localization Negative Regulation Of Astrocyte Differentiation Neurotransmitter Biosynthetic Process Histamine Transport Quaternary Ammonium Group Transport Midgut Development Anatomical Structure Arrangement Negative Regulation Of JAK-STAT Cascade Cell Migration In Hindbrain Neurotransmitter Metabolic Process Regulation Of Astrocyte Differentiation Drug Transmembrane Transport Negative Regulation Of Glial Cell Differentiation Ammonium Transmembrane Transport Organic Cation Transport Drug Transport Adult Walking Behavior Cerebellum Morphogenesis Hindbrain Morphogenesis Ventral Spinal Cord Development Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Axonogenesis Ammonium Transport Regulation Of Glial Cell Differentiation Cerebral Cortex Cell Migration Regulation Of JAK-STAT Cascade Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Gliogenesis Body Fluid Secretion Spinal Cord Development Neurotransmitter Secretion Adult Locomotory Behavior Cerebellum Development Negative Regulation Of Neuron Projection Development Cellular Localization Metencephalon Development Digestive Tract Development Regulation Of Neurotransmitter Levels Dendrite Development Negative Regulation Of Cell Projection Organization Digestive System Development	Nitrogen Compound Metabolic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process MRNA Catabolic Process Male Germ-line Stem Cell Asymmetric Division Glycosaminoglycan Metabolic Process RNA Catabolic Process Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Cellular Response To UV-B Skeletal Muscle Acetylcholine-gated Channel Clustering RNA Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Translation Involved In Gene Silencing By MiRNA
Tagcloud ?		10a 184a1 184b5 3p21 cacna2d2 closest combinated demethylating deoxycytidine deregulated epigenetically flanking hyal1 hyal2 isoform nprl2 rassf1 rassf1a rassf1c sema3b seventeen silenced spearman tmem115 trichostatin trimethylated tusc2 unmethylated zmynd10	4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 ggt1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc47a1 wu
Tagcloud (Difference) ?		10a 184a1 184b5 3p21 cacna2d2 closest combinated demethylating deoxycytidine deregulated epigenetically flanking hyal1 hyal2 isoform nprl2 rassf1 rassf1a rassf1c sema3b seventeen silenced spearman tmem115 trichostatin trimethylated tusc2 unmethylated zmynd10	4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 ggt1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc47a1 wu
Tagcloud (Intersection) ?