HYAL3 and BOLL

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HYAL3	BOLL
Name		hyaluronidase 3	boule RNA binding protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Acrosomal Membrane Extracellular Region Lysosome Endosome Early Endosome Endoplasmic Reticulum Plasma Membrane Membrane Cytoplasmic Vesicle Sperm Midpiece	Cytoplasm
	Molecular Function	Virus Receptor Activity Hyalurononglucosaminidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hyaluronoglucuronidase Activity	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Activator Activity Identical Protein Binding
	Biological Process	Ovarian Follicle Atresia Carbohydrate Metabolic Process Inflammatory Response Single Fertilization Penetration Of Zona Pellucida Response To Virus Hyaluronan Catabolic Process Response To Antibiotic Cartilage Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To UV-B Negative Regulation Of Ovarian Follicle Development Positive Regulation Of Acrosomal Vesicle Exocytosis	Regulation Of Translation Spermatogenesis Cell Differentiation Positive Regulation Of Translational Initiation Meiotic Cell Cycle 3'-UTR-mediated MRNA Stabilization
Pathways		CS/DS degradation Hyaluronan degradation	None
GWAS		Age at first birth ( 27798627 ) Basophil count ( 32888494 ) Body mass index ( 29273807 ) Schizophrenia ( 28991256 ) Sleep duration (short sleep) ( 30846698 )	Asthma ( 31361310 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Intracranial aneurysm ( 18997786 ) Morning person ( 30696823 ) Rheumatoid arthritis ( 32868391 ) Schizophrenia ( 29483656 25056061 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Novel Interactors		None recorded	1 novel interactors: AGPS
Interacting Genes		4 interacting genes: BOLL CAMK2A DAB1 SLC22A2	37 interacting genes: AGRN ARID5A ATXN2L C1orf94 CBX2 DAZ1 DAZ4 DCANP1 EHHADH FAM168A FOXD4L1 HNRNPLL HYAL3 HYPK INO80B KRTAP19-3 NAF1 NPBWR2 PATZ1 PHF1 POGZ POM121 PRR34 RBFOX2 RBPMS RBPMS2 RHOXF2 SEMA3B SERF2 SNRPC SPMIP2 SYCE1L TCEA2 TFG ZBTB32 ZC3H10 ZNF385C
Entrez ID		8372	66037
HPRD ID		04948	07314
Ensembl ID		ENSG00000186792	ENSG00000152430
Uniprot IDs		O43820	Q8N9W6
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Peptidyl-threonine Autophosphorylation Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Endocannabinoid Signaling Pathway Lateral Motor Column Neuron Migration Cerebellum Structural Organization Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Spinal Cord Motor Neuron Migration Radial Glia Guided Migration Of Purkinje Cell Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Spermidine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Amine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Thiamine Transmembrane Transport Acetylcholine Transmembrane Transporter Activity Radial Glia-guided Pyramidal Neuron Migration Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Glutamate Receptor Binding Toxin Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Polyamine Transmembrane Transport Ventral Spinal Cord Development Serotonin Uptake Choline Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Norepinephrine Transport Histamine Transport L-arginine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity L-arginine Transmembrane Transport Amine Transport Catecholamine Uptake Dopamine Uptake Cell Migration In Hindbrain Reelin-mediated Signaling Pathway	Nucleic Acid Binding MRNA Binding Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Binding Nucleus Translation Activator Activity Regulation Of Alternative MRNA Splicing, Via Spliceosome