UCK1 and KLHL2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, pull down, imaging technique, enzymatic study, affinity chromatography technology)

		UCK1	KLHL2
Description		uridine-cytidine kinase 1	kelch like family member 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection
	Molecular Function	Nucleotide Binding Uridine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cytidine Kinase Activity	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	CMP Biosynthetic Process UMP Salvage CTP Salvage	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Pyrimidine salvage	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		1 interacting genes: KLHL2	29 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID		83549	11275
HPRD ID		18256	09311
Ensembl ID		ENSG00000130717	ENSG00000109466
Uniprot IDs		A0A024R8E7 A0A0S2Z5Y6 Q9HA47	B4DFZ5 E9PEX9 O95198
PDB IDs		2JEO 2UVQ	2XN4 4CHB
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis
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