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HIST1H2BC and TP53BP2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
HIST1H2BC
TP53BP2
Gene Name
histone cluster 1, H2bc
tumor protein p53 binding protein 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Nucleus
Cytoplasm
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Protein Heterodimerization Activity
SH3/SH2 Adaptor Activity
Protein Binding
SH3 Domain Binding
Identical Protein Binding
NF-kappaB Binding
Biological Process
Innate Immune Response In Mucosa
Chromatin Organization
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Gram-positive Bacterium
Cell Cycle
Signal Transduction
Central Nervous System Development
Heart Development
Embryo Development Ending In Birth Or Egg Hatching
Positive Regulation Of Signal Transduction
Response To Ionizing Radiation
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
Chromatin organization
HDACs deacetylate histones
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Bilirubin levels (
19414484
)
Protein-Protein Interactions
2 interactors:
COPRS
TP53BP2
58 interactors:
APP
ATPAF2
ATXN7
BAIAP2
BCL2
BCL2L1
CCDC92
CSNK2B
CWF19L2
DCUN1D1
EEF1A1
GRB2
HIST1H2BC
HNRNPUL1
KIF5A
LMO4
MAGI1
MAPK8IP2
MRPL20
MTMR14
NAE1
NDC80
NUTM1
OTUB2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CB
PPP1CC
PRKAB2
PRPF31
PTN
RELA
SIAH1
SIAH2
SSX2IP
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TXLNA
UBASH3A
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YWHAG
YWHAQ
ZGPAT
ZNF26
Entrez ID
8347
7159
HPRD ID
13656
11803
Ensembl ID
ENSG00000143514
Uniprot IDs
B2R4S9
P62807
Q13625
PDB IDs
1YCS
2UWQ
4A63
Enriched GO Terms of Interacting Partners
?
Histone H4-R3 Methylation
Histone Arginine Methylation
Peptidyl-arginine Methylation
Neuron Death
Neuron Apoptotic Process
Response To Radiation
Regulation Of Signal Transduction
Regulation Of Signaling
Response To External Stimulus
Negative Regulation Of Signal Transduction
Entrainment Of Circadian Clock By Photoperiod
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Negative Regulation Of Signaling
Photoperiodism
Entrainment Of Circadian Clock
Positive Regulation Of Apoptotic Signaling Pathway
Cell Part Morphogenesis
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Metabolic Process
Cell Morphogenesis Involved In Neuron Differentiation
Regulation Of Phosphorylation
Response To Light Stimulus
Protein Modification By Small Protein Conjugation
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Cell Cycle
Neuron Projection Morphogenesis
Regulation Of Mitochondrion Organization
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Cell Projection Morphogenesis
Axonogenesis
Cellular Protein Modification Process
Positive Regulation Of Signal Transduction
Regulation Of Protein Phosphorylation
Regulation Of Phosphorus Metabolic Process
Cell Morphogenesis
Regulation Of Protein Metabolic Process
Cell Morphogenesis Involved In Differentiation
Regulation Of Cellular Protein Metabolic Process
Response To Gamma Radiation
Axon Development
Regulation Of Extrinsic Apoptotic Signaling Pathway
Mitotic Cell Cycle
Generation Of Neurons
Nervous System Development
Cellular Response To Ionizing Radiation
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Mitochondrion Organization
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Innate Immune Response
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Neuron Projection Development
Neurogenesis
Anatomical Structure Morphogenesis
Tagcloud
?
adenovirus
angiotensin
apoptosis
array
at2r
bag3
bmp6
bmp7
bnipi
cytokine
downregulation
du145
gadd45a
hrk
il6
il8
mapk
microrna
next
numerous
p44
pc
r2
silence
sirnas
tnfsf10
trail
transduced
utilized
Tagcloud (Difference)
?
adenovirus
angiotensin
apoptosis
array
at2r
bag3
bmp6
bmp7
bnipi
cytokine
downregulation
du145
gadd45a
hrk
il6
il8
mapk
microrna
next
numerous
p44
pc
r2
silence
sirnas
tnfsf10
trail
transduced
utilized
Tagcloud (Intersection)
?