FZD1 and DLG2

Number of citations: 0 (PubMedID 12067714)
Data Source: HPRD (two hybrid)

		FZD1	DLG2
Name		frizzled class receptor 1	discs large MAGUK scaffold protein 2
Structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Wnt Signalosome	Cytosol Plasma Membrane Adherens Junction Voltage-gated Potassium Channel Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Axon Neuromuscular Junction Cell Projection Neuron Projection Perikaryon Juxtaparanode Region Of Axon Synapse Postsynaptic Density Membrane Axon Cytoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity	GMP Kinase Activity Protein Binding Kinase Binding Protein Kinase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Xenobiotic Stimulus Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Autocrine Signaling Non-canonical Wnt Signaling Pathway Astrocyte-dopaminergic Neuron Signaling Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hard Palate Development Canonical Wnt Signaling Pathway Ventricular Septum Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Presynapse Assembly Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Mesenchymal Stem Cell Differentiation	Chemical Synaptic Transmission Nervous System Development Protein Localization To Synapse Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport
Pathways		TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
GWAS		Blond vs. brown/black hair color ( 30531825 ) Dental caries ( 23259602 ) Pulse pressure ( 27841878 ) Schizophrenia ( 31735061 ) Systolic blood pressure ( 27841878 )	Adult body size ( 32376654 ) Age at first sexual intercourse ( 27089180 ) Attention function in attention deficit hyperactive disorder ( 26174813 ) BMI at adiposity rebound ( 31840077 ) Body fat mass ( 28552196 ) Body mass index ( 28552196 ) Brain morphology (MOSTest) ( 32665545 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 ) Chronic obstructive pulmonary disease ( 25584925 ) Chronic periodontitis ( 25008200 ) Estrogen level change in anastrozole-treated breast cancer ( 32701512 ) Familial squamous cell lung carcinoma ( 29924316 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Height ( 28552196 ) Influenza A (H1N1) infection ( 26379185 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Lung adenocarcinoma (survival time) in never smokers ( 32699080 ) Migraine without aura ( 28952330 ) Mild influenza (H1N1) infection ( 26379185 ) Modic changes ( 30808802 ) Myopia ( 27182965 ) Nicotine dependence symptom count ( 25555482 ) Obesity-related traits ( 23251661 ) Oily fish consumption ( 32066663 ) Pallidum volume ( 31530798 ) Parkinson's disease ( 32201043 32310270 28892059 28011712 25064009 17052657 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Phospholipid levels (plasma) ( 22359512 ) Pork consumption ( 32066663 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Protein quantitative trait loci ( 18464913 ) Putamen volume ( 29147026 ) Refractive error ( 32231278 ) Response to fenofibrate (triglyceride levels) ( 27002377 ) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627 ) Schizophrenia ( 30285260 ) Schizophrenia x sex interaction ( 34099189 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Subcortical brain region volumes ( 25607358 ) Trunk fat mass ( 28552196 ) Type 2 diabetes ( 31049640 ) Urate levels in overweight individuals ( 25811787 ) Weight ( 28552196 ) Wilms tumor ( 22544364 )
Interacting Genes		6 interacting genes: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A	54 interacting genes: ABCA1 AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DSCAM ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VANGL2 VTN WNT3A
Entrez ID		8321	1740
HPRD ID		04558	04663
Ensembl ID		ENSG00000157240	ENSG00000150672
Uniprot IDs		Q9UP38	A0A3B3ISW2 A0A5F9ZH92 A0A994J570 A0A994J587 A0A994J5T6 A0A994J7P1 A0A994J7Q5 A0A994J819 A0A994J822 B5MCC5 B7Z2T4 E9PIJ9 E9PN83 Q15700
PDB IDs		8J9N 8J9O	2BYG 2HE2
GO Terms Enriched among Interactors		Midbrain Dopaminergic Neuron Differentiation Frizzled Binding Dopaminergic Neuron Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Cellular Response To Retinoic Acid Endocytic Vesicle Membrane Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Response To Retinoic Acid Receptor Ligand Activity Central Nervous System Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Collateral Sprouting In Absence Of Injury Cell Fate Commitment Cytokine Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Chemotaxis Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Axonogenesis Wnt Signaling Pathway Cell Proliferation In Midbrain Regulation Of Developmental Growth Regulation Of Anatomical Structure Morphogenesis Regulation Of Axon Extension Regulation Of Animal Organ Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Projection Organization Neuron Differentiation Regulation Of Neurogenesis Negative Regulation Of Developmental Growth Golgi Lumen Signaling Receptor Binding System Development Mammary Gland Epithelium Development Positive Regulation Of Collateral Sprouting Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Neurogenesis Regulation Of Nervous System Development Juxtaparanode Region Of Axon Negative Regulation Of Neuron Projection Development Cellular Response To Lipid Wnt Signalosome Secondary Palate Development Presynapse Assembly Neuron Projection Development Cellular Response To Potassium Ion Negative Regulation Of Neurogenesis Regulation Of Neuron Projection Arborization Negative Regulation Of Nervous System Development Regulation Of Axonogenesis	Postsynaptic Density Membrane Synapse Glutamatergic Synapse Postsynaptic Membrane PDZ Domain Binding Regulation Of Membrane Potential Signaling Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Communication Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Chemical Synaptic Transmission Postsynaptic Density Trans-synaptic Signaling Modulation Of Chemical Synaptic Transmission Metal Ion Transport Modulation Of Excitatory Postsynaptic Potential Cell-cell Signaling Glutamate Receptor Signaling Pathway Plasma Membrane Regulation Of System Process Protein Localization To Synapse Monoatomic Ion Transport Dendritic Spine Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Signaling Regulation Of Cell Communication Regulation Of Synapse Organization Protein Localization To Cell Junction Presynapse Assembly Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synapse Assembly Monoatomic Ion Channel Activity Inorganic Ion Transmembrane Transport NMDA Glutamate Receptor Activity Presynapse Organization Regulation Of Nervous System Process Calcium Ion Transport Synaptic Transmission, Glutamatergic