FZD1 and DLG2

Number of citations of the paper that reports this interaction (PMID 12067714)
9

Data Source:
HPRD (two hybrid)

		FZD1	DLG2
Gene Name		frizzled class receptor 1	discs, large homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane
	Molecular Function	G-protein Coupled Receptor Activity Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of Catenin Import Into Nucleus Autocrine Signaling Non-canonical Wnt Signaling Pathway Response To Drug Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Hard Palate Development Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway
Drugs
Diseases
GWAS		Dental caries ( 23259602)	Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)
Protein-Protein Interactions		6 interactors: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A	40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A
Entrez ID		8321	1740
HPRD ID		04558	04663
Ensembl ID		ENSG00000157240	ENSG00000150672
Uniprot IDs		Q9UP38	B7Z2T4 E9PN83 Q15700
PDB IDs			2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Activity Positive Regulation Of Receptor Activity Cellular Response To Retinoic Acid Negative Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Response To Retinoic Acid Negative Regulation Of Axon Extension Negative Regulation Of Chemotaxis Mammary Gland Development Cellular Response To Acid Chemical Positive Regulation Of Collateral Sprouting In Absence Of Injury Regulation Of Behavior Cell Morphogenesis Involved In Differentiation Wnt Signaling Pathway Regulation Of Developmental Growth Cell Fate Commitment Negative Regulation Of Axonogenesis Cell-cell Signaling Regulation Of Axon Extension Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Nervous System Development Negative Regulation Of Developmental Growth Axon Guidance Cell Morphogenesis Receptor Localization To Synapse Mammary Gland Epithelium Development Neuron Differentiation Cellular Response To Lipid Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Embryonic Development Negative Regulation Of Neuron Projection Development Gland Development Positive Regulation Of Collateral Sprouting Regulation Of Cell Size Axonogenesis Regulation Of Chemotaxis Negative Regulation Of Cell Projection Organization Axon Development Negative Regulation Of Cell Growth Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Developmental Growth Regulation Of Axonogenesis Chemotaxis Regulation Of Growth Generation Of Neurons Protein Localization To Synapse Neuron Projection Morphogenesis Tissue Morphogenesis Regulation Of Organ Morphogenesis	Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly
Tagcloud ?		450k bnc1 clinicopathologic clustering comprehensively cpg cxxc5 cyb5r2 cytosine densities dysregulation false harbors hierarchical il1 illumina inactivation interrogating intraepithelial lmx1b methylated methylation myriad pca prostatic rpl39l syn2 top znf783	17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?		450k bnc1 clinicopathologic clustering comprehensively cpg cxxc5 cyb5r2 cytosine densities dysregulation false harbors hierarchical il1 illumina inactivation interrogating intraepithelial lmx1b methylated methylation myriad pca prostatic rpl39l syn2 top znf783	17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?