FZD1 and WNT3

Number of citations of the paper that reports this interaction (PMID 10557084)
26

Data Source:
HPRD (in vivo)

		FZD1	WNT3
Gene Name		frizzled class receptor 1	wingless-type MMTV integration site family, member 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Activity Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity	Frizzled Binding Protein Binding Protein Domain Specific Binding Receptor Agonist Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of Catenin Import Into Nucleus Autocrine Signaling Non-canonical Wnt Signaling Pathway Response To Drug Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Hard Palate Development Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Cell Morphogenesis Mesoderm Formation Gamete Generation Axon Guidance Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Positive Regulation Of Gene Expression Neuron Differentiation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Spemann Organizer Formation At The Anterior End Of The Primitive Streak Canonical Wnt Signaling Pathway Limb Bud Formation Head Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Dental caries ( 23259602)	Parkinson's disease ( 22451204 21812969)
Protein-Protein Interactions		6 interactors: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A	1 interactors: FZD1
Entrez ID		8321	7473
HPRD ID		04558	01318
Ensembl ID		ENSG00000157240	ENSG00000108379
Uniprot IDs		Q9UP38	P56703
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Activity Positive Regulation Of Receptor Activity Cellular Response To Retinoic Acid Negative Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Response To Retinoic Acid Negative Regulation Of Axon Extension Negative Regulation Of Chemotaxis Mammary Gland Development Cellular Response To Acid Chemical Positive Regulation Of Collateral Sprouting In Absence Of Injury Regulation Of Behavior Cell Morphogenesis Involved In Differentiation Wnt Signaling Pathway Regulation Of Developmental Growth Cell Fate Commitment Negative Regulation Of Axonogenesis Cell-cell Signaling Regulation Of Axon Extension Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Nervous System Development Negative Regulation Of Developmental Growth Axon Guidance Cell Morphogenesis Receptor Localization To Synapse Mammary Gland Epithelium Development Neuron Differentiation Cellular Response To Lipid Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Embryonic Development Negative Regulation Of Neuron Projection Development Gland Development Positive Regulation Of Collateral Sprouting Regulation Of Cell Size Axonogenesis Regulation Of Chemotaxis Negative Regulation Of Cell Projection Organization Axon Development Negative Regulation Of Cell Growth Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Developmental Growth Regulation Of Axonogenesis Chemotaxis Regulation Of Growth Generation Of Neurons Protein Localization To Synapse Neuron Projection Morphogenesis Tissue Morphogenesis Regulation Of Organ Morphogenesis	Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Autocrine Signaling Muscular Septum Morphogenesis Membranous Septum Morphogenesis Hard Palate Development Negative Regulation Of Catenin Import Into Nucleus Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Catenin Import Into Nucleus Non-canonical Wnt Signaling Pathway Ventricular Septum Morphogenesis Negative Regulation Of BMP Signaling Pathway Ventricular Septum Development Cardiac Septum Morphogenesis Outflow Tract Morphogenesis Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Negative Regulation Of Protein Import Into Nucleus Cardiac Septum Development Negative Regulation Of Protein Localization To Nucleus Regulation Of BMP Signaling Pathway Negative Regulation Of Intracellular Protein Transport Canonical Wnt Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Palate Development Cardiac Ventricle Development Regulation Of Embryonic Development Negative Regulation Of Intracellular Transport Positive Regulation Of Canonical Wnt Signaling Pathway Osteoblast Differentiation Cardiac Chamber Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Protein Import Into Nucleus Regulation Of Organ Morphogenesis Negative Regulation Of Protein Transport Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleocytoplasmic Transport Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Protein Transport Wnt Signaling Pathway Muscle Organ Development Ossification Regulation Of Wnt Signaling Pathway Stem Cell Differentiation
Tagcloud ?		450k bnc1 clinicopathologic clustering comprehensively cpg cxxc5 cyb5r2 cytosine densities dysregulation false harbors hierarchical il1 illumina inactivation interrogating intraepithelial lmx1b methylated methylation myriad pca prostatic rpl39l syn2 top znf783	17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1
Tagcloud (Difference) ?		450k bnc1 clinicopathologic clustering comprehensively cpg cxxc5 cyb5r2 cytosine densities dysregulation false harbors hierarchical il1 illumina inactivation interrogating intraepithelial lmx1b methylated methylation myriad pca prostatic rpl39l syn2 top znf783	17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1
Tagcloud (Intersection) ?