FZD1 and WNT2

Number of citations: 0 (PubMedID 10557084)
Data Source: HPRD (in vitro, in vivo)

		FZD1	WNT2
Name		frizzled class receptor 1	Wnt family member 2
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Wnt Signalosome	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Wnt Signalosome
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity
	Biological Process	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Xenobiotic Stimulus Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Autocrine Signaling Non-canonical Wnt Signaling Pathway Astrocyte-dopaminergic Neuron Signaling Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hard Palate Development Canonical Wnt Signaling Pathway Ventricular Septum Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Presynapse Assembly Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Mesenchymal Stem Cell Differentiation	Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Mesenchymal Cell Proliferation Wnt Signaling Pathway Neurogenesis Neuron Differentiation Cell Proliferation In Midbrain Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Animal Organ Development System Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Neurogenesis Atrial Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Lung Induction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Epithelial Cell Proliferation Involved In Lung Morphogenesis Labyrinthine Layer Blood Vessel Development Iris Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Midbrain Dopaminergic Neuron Differentiation
Pathways		TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
GWAS		Blond vs. brown/black hair color ( 30531825 ) Dental caries ( 23259602 ) Pulse pressure ( 27841878 ) Schizophrenia ( 31735061 ) Systolic blood pressure ( 27841878 )	Dupuytren's disease ( 21732829 28886342 ) Inflammatory bowel disease ( 28067908 ) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573 ) Tonsillectomy ( 27182965 28928442 ) Ulcerative colitis ( 28067908 ) Uterine fibroids ( 31649266 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		6 interacting genes: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A	8 interacting genes: AQP5 FZD1 FZD9 HCK RRAGC SFRP1 UQCR11 WNT3A
Entrez ID		8321	7472
HPRD ID		04558	00999
Ensembl ID		ENSG00000157240	ENSG00000105989
Uniprot IDs		Q9UP38	A0A384MDX3 P09544
PDB IDs		8J9N 8J9O	Not available
GO Terms Enriched among Interactors		Midbrain Dopaminergic Neuron Differentiation Frizzled Binding Dopaminergic Neuron Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Cellular Response To Retinoic Acid Endocytic Vesicle Membrane Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Response To Retinoic Acid Receptor Ligand Activity Central Nervous System Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Collateral Sprouting In Absence Of Injury Cell Fate Commitment Cytokine Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Chemotaxis Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Axonogenesis Wnt Signaling Pathway Cell Proliferation In Midbrain Regulation Of Developmental Growth Regulation Of Anatomical Structure Morphogenesis Regulation Of Axon Extension Regulation Of Animal Organ Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Projection Organization Neuron Differentiation Regulation Of Neurogenesis Negative Regulation Of Developmental Growth Golgi Lumen Signaling Receptor Binding System Development Mammary Gland Epithelium Development Positive Regulation Of Collateral Sprouting Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Neurogenesis Regulation Of Nervous System Development Juxtaparanode Region Of Axon Negative Regulation Of Neuron Projection Development Cellular Response To Lipid Wnt Signalosome Secondary Palate Development Presynapse Assembly Neuron Projection Development Cellular Response To Potassium Ion Negative Regulation Of Neurogenesis Regulation Of Neuron Projection Arborization Negative Regulation Of Nervous System Development Regulation Of Axonogenesis	Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Wnt-protein Binding Dopaminergic Neuron Differentiation Frizzled Binding Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Presynapse Assembly Wnt Receptor Activity Positive Regulation Of Wnt Signaling Pathway Presynapse Organization Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Cell Surface Regulation Of Cell Junction Assembly Somitogenesis Segmentation Positive Regulation Of Neural Precursor Cell Proliferation Mesoderm Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of BMP Signaling Pathway Convergent Extension Involved In Somitogenesis Neuron Differentiation Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Positive Regulation Of Mesodermal Cell Fate Specification Regulation Of Animal Organ Morphogenesis Regulation Of Apoptotic Signaling Pathway Signaling Receptor Binding Tissue Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Receptor Clustering Neural Precursor Cell Proliferation Axis Elongation Involved In Somitogenesis Positive Regulation Of Cell Fate Specification Regulation Of Postsynapse To Nucleus Signaling Pathway Paraxial Mesodermal Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Cellular Response To Lipid Positive Regulation Of Cellular Component Organization Regulation Of BMP Signaling Pathway