FZD1

Description		frizzled class receptor 1
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Wnt Signalosome
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity
	Biological Process	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Xenobiotic Stimulus Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Autocrine Signaling Non-canonical Wnt Signaling Pathway Astrocyte-dopaminergic Neuron Signaling Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hard Palate Development Canonical Wnt Signaling Pathway Ventricular Septum Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Presynapse Assembly Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Dental caries ( 23259602) Pulse pressure ( 27841878) Schizophrenia ( 31735061) Systolic blood pressure ( 27841878)
Interacting Genes		6 interacting genes: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A
Entrez ID		8321
HPRD ID		04558
Ensembl ID		ENSG00000157240
Uniprot IDs		Q9UP38
PDB IDs		8J9N 8J9O
Enriched GO Terms of Interacting Partners?		Midbrain Dopaminergic Neuron Differentiation Frizzled Binding Dopaminergic Neuron Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Cellular Response To Retinoic Acid Endocytic Vesicle Membrane Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Response To Retinoic Acid Receptor Ligand Activity Central Nervous System Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Collateral Sprouting In Absence Of Injury Cell Fate Commitment Cytokine Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Chemotaxis Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Axonogenesis Wnt Signaling Pathway Cell Proliferation In Midbrain Regulation Of Developmental Growth Regulation Of Anatomical Structure Morphogenesis Regulation Of Axon Extension Regulation Of Animal Organ Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Projection Organization Neuron Differentiation Regulation Of Neurogenesis Negative Regulation Of Developmental Growth Golgi Lumen Signaling Receptor Binding System Development Mammary Gland Epithelium Development Positive Regulation Of Collateral Sprouting Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Neurogenesis Regulation Of Nervous System Development Juxtaparanode Region Of Axon Negative Regulation Of Neuron Projection Development Cellular Response To Lipid Wnt Signalosome Secondary Palate Development Presynapse Assembly Neuron Projection Development Cellular Response To Potassium Ion Negative Regulation Of Neurogenesis Regulation Of Neuron Projection Arborization Negative Regulation Of Nervous System Development Regulation Of Axonogenesis
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