FZD1

Gene Name		frizzled class receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane
	Molecular Function	G-protein Coupled Receptor Activity Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of Catenin Import Into Nucleus Autocrine Signaling Non-canonical Wnt Signaling Pathway Response To Drug Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Hard Palate Development Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway
Drugs
Diseases
GWAS		Dental caries ( 23259602)
Protein-protein Interactions		6 interactors: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A
Entrez ID		8321
HPRD ID		04558
Ensembl ID		ENSG00000157240
Uniprot IDs		Q9UP38
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Activity Positive Regulation Of Receptor Activity Cellular Response To Retinoic Acid Negative Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Response To Retinoic Acid Negative Regulation Of Axon Extension Negative Regulation Of Chemotaxis Mammary Gland Development Cellular Response To Acid Chemical Positive Regulation Of Collateral Sprouting In Absence Of Injury Regulation Of Behavior Cell Morphogenesis Involved In Differentiation Wnt Signaling Pathway Regulation Of Developmental Growth Cell Fate Commitment Negative Regulation Of Axonogenesis Cell-cell Signaling Regulation Of Axon Extension Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Nervous System Development Negative Regulation Of Developmental Growth Axon Guidance Cell Morphogenesis Receptor Localization To Synapse Mammary Gland Epithelium Development Neuron Differentiation Cellular Response To Lipid Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Embryonic Development Negative Regulation Of Neuron Projection Development Gland Development Positive Regulation Of Collateral Sprouting Regulation Of Cell Size Axonogenesis Regulation Of Chemotaxis Negative Regulation Of Cell Projection Organization Axon Development Negative Regulation Of Cell Growth Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Developmental Growth Regulation Of Axonogenesis Chemotaxis Regulation Of Growth Generation Of Neurons Protein Localization To Synapse Neuron Projection Morphogenesis Tissue Morphogenesis Regulation Of Organ Morphogenesis
Tagcloud ?		450k bnc1 clinicopathologic clustering comprehensively cpg cxxc5 cyb5r2 cytosine densities dysregulation false harbors hierarchical il1 illumina inactivation interrogating intraepithelial lmx1b methylated methylation myriad pca prostatic rpl39l syn2 top znf783