FZD1 and WNT5A

Number of citations: 0 (PubMedID 10557084)
Data Source: HPRD (in vivo)

		FZD1	WNT5A
Name		frizzled class receptor 1	Wnt family member 5A
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Wnt Signalosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity	Signaling Receptor Binding Frizzled Binding Receptor Tyrosine Kinase-like Orphan Receptor Binding Cytokine Activity Protein Binding Phospholipid Binding Protein Domain Specific Binding Receptor Ligand Activity Chemoattractant Activity Involved In Axon Guidance
	Biological Process	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Xenobiotic Stimulus Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Autocrine Signaling Non-canonical Wnt Signaling Pathway Astrocyte-dopaminergic Neuron Signaling Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hard Palate Development Canonical Wnt Signaling Pathway Ventricular Septum Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Presynapse Assembly Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Mesenchymal Stem Cell Differentiation	Establishment Of Planar Polarity Somitogenesis Positive Regulation Of Cytokine Production Kidney Development Epithelial To Mesenchymal Transition Neural Tube Closure Positive Regulation Of Endothelial Cell Proliferation Heart Looping Morphogenesis Of An Epithelium Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Cytokine Production Involved In Immune Response Primary Heart Field Specification Secondary Heart Field Specification Ventricular Septum Development Atrial Septum Development Type B Pancreatic Cell Development Pericardium Morphogenesis Axis Elongation Optic Cup Formation Involved In Camera-type Eye Development Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway JNK Cascade Determination Of Left/right Symmetry Axonogenesis Axon Guidance Hindgut Morphogenesis Midgut Development Intracellular Protein Localization Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Anterior/posterior Axis Specification, Embryo Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Epithelial Cell Migration Macrophage Derived Foam Cell Differentiation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Olfactory Bulb Interneuron Development Neural Tube Development Neurogenesis Cell Differentiation Neuron Differentiation Keratinocyte Differentiation Lung Development Embryonic Limb Morphogenesis BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Midbrain Development Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Protein Localization Positive Regulation Of Rac Protein Signal Transduction Limb Morphogenesis Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Chemoattraction Of Serotonergic Neuron Axon Chemorepulsion Of Dopaminergic Neuron Axon Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Inner Ear Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Cell Fate Commitment Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Ossification Positive Regulation Of Endocytosis Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Development Of Primary Male Sexual Characteristics Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Paraxial Mesoderm Formation Digestive Tract Morphogenesis Notochord Morphogenesis Embryonic Skeletal System Development Genitalia Development Neuron Projection Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Hypophysis Morphogenesis Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Synapse Organization Negative Chemotaxis Cartilage Development Positive Regulation Of Timing Of Anagen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Synapse Assembly Convergent Extension Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Uterus Development Cervix Development Vagina Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Urinary Bladder Development Face Development Positive Regulation Of Type I Interferon-mediated Signaling Pathway Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Tube Closure Mesenchymal-epithelial Cell Signaling Negative Regulation Of Prostatic Bud Formation Mammary Gland Branching Involved In Thelarche Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Response To Cytokine Stimulus Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Mesodermal To Mesenchymal Transition Involved In Gastrulation Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Cartilage Development Somite Development Secondary Palate Development Thymocyte Apoptotic Process Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Retinoic Acid Cellular Response To Type II Interferon Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Stem Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Melanocyte Proliferation Presynapse Assembly Postsynapse Assembly Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Meiotic Nuclear Division Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Localization To Synapse Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Cell Proliferation In Midbrain Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
GWAS		Blond vs. brown/black hair color ( 30531825 ) Dental caries ( 23259602 ) Pulse pressure ( 27841878 ) Schizophrenia ( 31735061 ) Systolic blood pressure ( 27841878 )	Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Height ( 28552196 ) Lung function (FEV1/FVC) ( 28166213 ) Metabolite levels ( 23823483 ) Type 2 diabetes ( 30130595 )
Interacting Genes		6 interacting genes: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A	3 interacting genes: FZD1 FZD5 ROR2
Entrez ID		8321	7474
HPRD ID		04558	01293
Ensembl ID		ENSG00000157240	ENSG00000114251
Uniprot IDs		Q9UP38	A0A384N611 B3KQX9 P41221
PDB IDs		8J9N 8J9O	Not available
GO Terms Enriched among Interactors		Midbrain Dopaminergic Neuron Differentiation Frizzled Binding Dopaminergic Neuron Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Cellular Response To Retinoic Acid Endocytic Vesicle Membrane Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Response To Retinoic Acid Receptor Ligand Activity Central Nervous System Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Collateral Sprouting In Absence Of Injury Cell Fate Commitment Cytokine Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Chemotaxis Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Axonogenesis Wnt Signaling Pathway Cell Proliferation In Midbrain Regulation Of Developmental Growth Regulation Of Anatomical Structure Morphogenesis Regulation Of Axon Extension Regulation Of Animal Organ Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Projection Organization Neuron Differentiation Regulation Of Neurogenesis Negative Regulation Of Developmental Growth Golgi Lumen Signaling Receptor Binding System Development Mammary Gland Epithelium Development Positive Regulation Of Collateral Sprouting Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Neurogenesis Regulation Of Nervous System Development Juxtaparanode Region Of Axon Negative Regulation Of Neuron Projection Development Cellular Response To Lipid Wnt Signalosome Secondary Palate Development Presynapse Assembly Neuron Projection Development Cellular Response To Potassium Ion Negative Regulation Of Neurogenesis Regulation Of Neuron Projection Arborization Negative Regulation Of Nervous System Development Regulation Of Axonogenesis	Wnt-protein Binding Wnt Receptor Activity Endothelial Cell Differentiation Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Vasculature Development Positive Regulation Of Osteoblast Differentiation Clathrin-coated Endocytic Vesicle Membrane Methanethiol Oxidase Activity G Protein-coupled Receptor Activity