CDC45 and CLSPN

Number of citations of the paper that reports this interaction (PubMedID 21478680)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CDC45	CLSPN
Description		cell division cycle 45	claspin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body CMG Complex	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	DNA Secondary Structure Binding DNA Binding Protein Binding Anaphase-promoting Complex Binding
	Biological Process	DNA Replication Checkpoint Signaling Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Mitotic DNA Replication Preinitiation Complex Assembly	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint Signaling
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription	Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		23 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CLSPN CSK LCK MAPK3 MCM10 MCM3 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	20 interacting genes: ATR BRCA1 CASP7 CDC45 CDC7 CHEK1 CSNK1G1 CSNK1G2 CSNK1G3 FZR1 POLE RAD17 RAD9A TIMELESS TIPIN TRIM21 USP20 USP28 USP29 USP7
Entrez ID		8318	63967
HPRD ID		09145	09257
Ensembl ID		ENSG00000093009	ENSG00000092853
Uniprot IDs		O75419	Q9HAW4
PDB IDs		5DGO 6XTX 6XTY 7PFO 7PLO	7AKO 7PFO 7PLO 8B9D
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation Origin Recognition Complex DNA Replication Origin Binding DNA Replication Nuclear Origin Of Replication Recognition Complex DNA Metabolic Process Chromosome, Telomeric Region Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Mitotic DNA Replication Checkpoint Signaling Nucleoplasm Regulation Of DNA Replication Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2/M Transition Checkpoint DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleotide Binding Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Damage Response Macromolecule Metabolic Process Mitotic DNA Replication Initiation Single-stranded DNA Binding Mitotic G2 DNA Damage Checkpoint Signaling Alpha DNA Polymerase:primase Complex Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Oncogene-induced Cell Senescence ATP Binding Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Cell Cycle CMG Complex MCM Complex Mitotic DNA Damage Checkpoint Signaling Cellular Response To Stress Double-strand Break Repair Via Break-induced Replication Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleolus Negative Regulation Of Mitotic Cell Cycle Replicative Senescence DNA Binding Regulation Of DNA-templated DNA Replication Initiation	Negative Regulation Of Cell Cycle Phase Transition DNA Repair DNA Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process DNA Damage Response Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage DNA Replication Checkpoint Signaling Cellular Response To Stress Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Cell Cycle Phase Transition Response To Stress Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle G2/M Phase Transition Intracellular Signal Transduction Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Signal Transduction Regulation Of DNA Replication Cysteine-type Peptidase Activity Nucleus Protein Modification Process Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cysteine-type Endopeptidase Activity Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Nucleoplasm Post-translational Protein Modification Deubiquitinase Activity Cysteine-type Deubiquitinase Activity Replication Fork Protection Complex Protein Deubiquitination Protein Serine/threonine Kinase Activity Replication Fork Arrest Mitotic G2 DNA Damage Checkpoint Signaling
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