CDC45 and TRAPPC3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CDC45	TRAPPC3
Description		cell division cycle 45	trafficking protein particle complex subunit 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body CMG Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol TRAPP Complex Cis-Golgi Network Membrane TRAPPII Protein Complex TRAPPIII Protein Complex
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	Protein Binding
	Biological Process	DNA Replication Checkpoint Signaling Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Mitotic DNA Replication Preinitiation Complex Assembly	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport Golgi Vesicle Transport COPII Vesicle Coating Vesicle Tethering
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs			Palmitic Acid Myristic acid S-palmitoyl-L-cysteine
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 30054594)
Interacting Genes		23 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CLSPN CSK LCK MAPK3 MCM10 MCM3 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	8 interacting genes: APP CDC45 LIG4 PLEKHF2 TRAPPC2 TRAPPC2B TRAPPC2L TRAPPC6A
Entrez ID		8318	27095
HPRD ID		09145	11644
Ensembl ID		ENSG00000093009	ENSG00000054116
Uniprot IDs		O75419	A0A087WWM0 A0A087WYS5 O43617
PDB IDs		5DGO 6XTX 6XTY 7PFO 7PLO	1SZ7 2C0J 2CFH 3KXC
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation Origin Recognition Complex DNA Replication Origin Binding DNA Replication Nuclear Origin Of Replication Recognition Complex DNA Metabolic Process Chromosome, Telomeric Region Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Mitotic DNA Replication Checkpoint Signaling Nucleoplasm Regulation Of DNA Replication Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2/M Transition Checkpoint DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleotide Binding Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Damage Response Macromolecule Metabolic Process Mitotic DNA Replication Initiation Single-stranded DNA Binding Mitotic G2 DNA Damage Checkpoint Signaling Alpha DNA Polymerase:primase Complex Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Oncogene-induced Cell Senescence ATP Binding Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Cell Cycle CMG Complex MCM Complex Mitotic DNA Damage Checkpoint Signaling Cellular Response To Stress Double-strand Break Repair Via Break-induced Replication Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleolus Negative Regulation Of Mitotic Cell Cycle Replicative Senescence DNA Binding Regulation Of DNA-templated DNA Replication Initiation	TRAPPIII Protein Complex TRAPP Complex COPII Vesicle Coating Vesicle Tethering Vesicle Coating TRAPPII Protein Complex Vesicle Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intracellular Transport Vesicle-mediated Transport Protein-containing Complex Assembly Golgi Vesicle Transport Protein-containing Complex Organization Cellular Localization Endoplasmic Reticulum Establishment Of Localization In Cell Cellular Component Assembly Perinuclear Region Of Cytoplasm Organelle Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Establishment Of Integrated Proviral Latency Mitotic DNA Replication Preinitiation Complex Assembly Endoplasmic Reticulum-Golgi Intermediate Compartment Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Viral Latency DNA Replication Preinitiation Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity DNA Replication Preinitiation Complex Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling
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