CDC45 and CSK

Number of citations of the paper that reports this interaction (PubMedID 14625311)
0

Data Source:
BioGRID (enzymatic study)

		CDC45	CSK
Description		cell division cycle 45	C-terminal Src kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body CMG Complex	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Extracellular Exosome
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Protein Kinase A Catalytic Subunit Binding Identical Protein Binding Metal Ion Binding Proline-rich Region Binding Protein Tyrosine Kinase Binding
	Biological Process	DNA Replication Checkpoint Signaling Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Mitotic DNA Replication Preinitiation Complex Assembly	Adaptive Immune Response Immune System Process Regulation Of Immune System Process Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance T Cell Costimulation Negative Regulation Of Interleukin-6 Production Adherens Junction Organization Intracellular Signal Transduction Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Regulation Of Multicellular Organismal Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription	GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains Integrin signaling Co-inhibition by PD-1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOH GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Negative regulation of FLT3
Drugs			Dasatinib Staurosporine TG-100801 Fostamatinib
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Blood pressure ( 21909110) Blood protein levels ( 30072576) Body mass index and systole blood pressure (pairwise) ( 33619380) Caffeine consumption ( 21490707) Coffee consumption ( 31959922) Diastolic blood pressure ( 19430483 26390057 19430479) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Hypertension ( 31513605) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Serum albumin levels ( 29403010) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Systolic blood pressure ( 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
Interacting Genes		23 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CLSPN CSK LCK MAPK3 MCM10 MCM3 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	51 interacting genes: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDC45 CDH5 CREBBP DAB2 DOK1 DOK2 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KANK4 KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PDPK1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 UBE2I ZAP70 ZNF212
Entrez ID		8318	1445
HPRD ID		09145	00496
Ensembl ID		ENSG00000093009	ENSG00000103653
Uniprot IDs		O75419	A8K3B6 B2R6Q4 P41240
PDB IDs		5DGO 6XTX 6XTY 7PFO 7PLO	1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation Origin Recognition Complex DNA Replication Origin Binding DNA Replication Nuclear Origin Of Replication Recognition Complex DNA Metabolic Process Chromosome, Telomeric Region Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Mitotic DNA Replication Checkpoint Signaling Nucleoplasm Regulation Of DNA Replication Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2/M Transition Checkpoint DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleotide Binding Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Damage Response Macromolecule Metabolic Process Mitotic DNA Replication Initiation Single-stranded DNA Binding Mitotic G2 DNA Damage Checkpoint Signaling Alpha DNA Polymerase:primase Complex Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Oncogene-induced Cell Senescence ATP Binding Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Cell Cycle CMG Complex MCM Complex Mitotic DNA Damage Checkpoint Signaling Cellular Response To Stress Double-strand Break Repair Via Break-induced Replication Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleolus Negative Regulation Of Mitotic Cell Cycle Replicative Senescence DNA Binding Regulation Of DNA-templated DNA Replication Initiation	Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Activation Of Immune Response Fc Receptor Signaling Pathway Focal Adhesion Positive Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Signaling Regulation Of Cell Communication Fc Receptor Mediated Stimulatory Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Protein Tyrosine Kinase Activity Intracellular Signal Transduction Protein Phosphorylation Immune System Process Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade T Cell Costimulation Positive Regulation Of Immune Response Regulation Of Programmed Cell Death Phosphorylation Anchoring Junction Regulation Of Immune Response Positive Regulation Of Immune System Process Membrane Raft Positive Regulation Of Multicellular Organismal Process Plasma Membrane SH2 Domain Binding Regulation Of Immune System Process Protein Kinase Activity Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Signal Complex Assembly Phosphotyrosine Residue Binding Negative Regulation Of Cell Communication
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