CDC45 and CDKN2A

Number of citations of the paper that reports this interaction (PMID 15232106)
88

Data Source:
HPRD (in vitro)

		CDC45	CDKN2A
Gene Name		cell division cycle 45	cyclin-dependent kinase inhibitor 2A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Pre-replicative Complex Cytoplasm Centrosome DNA Replication Preinitiation Complex Replication Fork Protection Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Nuclear Body Senescence-associated Heterochromatin Focus Protein Complex
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding 3'-5' DNA Helicase Activity	P53 Binding DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Poly(A) RNA Binding NF-kappaB Binding Ubiquitin-protein Transferase Inhibitor Activity MDM2/MDM4 Family Protein Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of Chromatin Silencing At Telomere DNA Duplex Unwinding Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Replication Preinitiation Complex Assembly	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Negative Regulation Of Cell-matrix Adhesion Transcription, DNA-templated RRNA Processing Negative Regulation Of Protein Kinase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Arrest Ras Protein Signal Transduction Negative Regulation Of Cell Proliferation Apoptotic Mitochondrial Changes Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Growth Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Protein Sumoylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Export From Nucleus Somatic Stem Cell Division Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of Cell Cycle Arrest Cellular Senescence Replicative Senescence Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cellular Senescence
Pathways		E2F mediated regulation of DNA replication Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Activation of the pre-replicative complex S Phase DNA strand elongation Cell Cycle, Mitotic Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Cell Cycle Checkpoints Mitotic G1-G1/S phases Unwinding of DNA	Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic Oxidative Stress Induced Senescence Cellular Senescence Oncogene Induced Senescence
Drugs
Diseases
GWAS			Abdominal aortic aneurysm ( 20622881) Breast cancer ( 23535729 20453838) Coronary artery calcification ( 23561647) Coronary heart disease ( 21626137 21971053 17554300 21378990) Endometriosis ( 23104006) Glioma ( 21531791 19578367) Intracranial aneurysm ( 18997786 20364137) Melanoma ( 21983787 19578364) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Platelet counts ( 22139419) Type 2 diabetes ( 21573907 18372903 20581827 19401414 17463246 17463248 17463249 23209189)
Protein-Protein Interactions		16 interactors: CAMK1G CDK4 CDKN1A CDKN2A CEP55 MCM10 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 TRAPPC3	94 interactors: ACLY ACTB ACTG1 ACTN4 AHNAK ANKRD12 ARFIP2 BCL2L1 BECN1 CARF CCDC183 CCND1 CCND2 CCNG1 CDC45 CDC5L CDC6 CDC7 CDK4 CDK6 CDKN2AIP CDKN2C CRELD2 CTBP2 DEAF1 E2F1 E4F1 EEF2 EGR1 EPHA3 FN1 GAPDH GGA1 GGA3 GMNN GSPT1 HIF1A HIST3H2BB HNRNPA2B1 HNRNPC HNRNPU HSP90AA1 HSP90AB1 HSPA4 HSPA8 HUWE1 KAT5 MAPK10 MAPK8 MCM10 MCM2 MCM5 MCM6 MDM2 MMRN1 MTR MYC MYL12A NCL NMI ORC4 PCNA PDCD6 PEX19 PLEKHA8 PPP1R9B PRKCA PSMC3 RIN2 RPS7 RUVBL2 SERTAD1 SIVA1 SLC4A1 SMARCA4 SNRPA SNRPB TBRG1 TDRD7 TP63 TPI1 TRIP12 TUBA1A TUBA1C TUBB TUBB4B UBE2A UBE4B USP26 WRN YY1 ZFP91 ZNF227 ZNF410
Entrez ID		8318	1029
HPRD ID		09145	02542
Ensembl ID		ENSG00000093009	ENSG00000147889
Uniprot IDs		O75419	G3XAG3 K7PML8 P42771 Q8N726
PDB IDs			1A5E 1BI7 1DC2 2A5E
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process DNA Replication Initiation DNA Replication Cell Cycle DNA-dependent DNA Replication DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change Nucleobase-containing Compound Metabolic Process DNA Conformation Change DNA Unwinding Involved In DNA Replication Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Arrest Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Hyperoxia Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Senescence Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Regulation Of B Cell Proliferation Positive Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Organ Regeneration Cell Aging Cell Proliferation Positive Regulation Of Cell Cycle Arrest Leading Strand Elongation Regulation Of Fibroblast Proliferation Senescence-associated Heterochromatin Focus Assembly Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cell Division	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle G1/S Transition Of Mitotic Cell Cycle Response To Stress Cellular Response To Stress Regulation Of Metabolic Process Regulation Of Cell Cycle Response To Abiotic Stimulus Cellular Response To DNA Damage Stimulus Response To Radiation Negative Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Mitotic Cell Cycle Cell Division Cellular Nitrogen Compound Metabolic Process Response To UV Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication DNA Replication Initiation Nitrogen Compound Metabolic Process Chromosome Organization Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process DNA Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Radiation Regulation Of Protein Metabolic Process DNA-dependent DNA Replication Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Proliferation Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Stimulus DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation
Tagcloud ?		atpgammas cmg cmgs congruencies cracked dimeric dissociating dnab duplex engages enters establishes eukaryotes explains gins handed helicase helicases helps hexamers matures mcm mcm2 separates spiral strands subcomplex subpopulation transitions	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?		atpgammas cmg cmgs congruencies cracked dimeric dissociating dnab duplex engages enters establishes eukaryotes explains gins handed helicase helicases helps hexamers matures mcm mcm2 separates spiral strands subcomplex subpopulation transitions	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Intersection) ?