CDC45

Gene Name		cell division cycle 45
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Pre-replicative Complex Cytoplasm Centrosome DNA Replication Preinitiation Complex Replication Fork Protection Complex
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding 3'-5' DNA Helicase Activity
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of Chromatin Silencing At Telomere DNA Duplex Unwinding Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		E2F mediated regulation of DNA replication Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Activation of the pre-replicative complex S Phase DNA strand elongation Cell Cycle, Mitotic Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Cell Cycle Checkpoints Mitotic G1-G1/S phases Unwinding of DNA
Drugs
Diseases
GWAS
Protein-protein Interactions		16 interactors: CAMK1G CDK4 CDKN1A CDKN2A CEP55 MCM10 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 TRAPPC3
Entrez ID		8318
HPRD ID		09145
Ensembl ID		ENSG00000093009
Uniprot IDs		O75419
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process DNA Replication Initiation DNA Replication Cell Cycle DNA-dependent DNA Replication DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change Nucleobase-containing Compound Metabolic Process DNA Conformation Change DNA Unwinding Involved In DNA Replication Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Arrest Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Hyperoxia Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Senescence Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Regulation Of B Cell Proliferation Positive Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Organ Regeneration Cell Aging Cell Proliferation Positive Regulation Of Cell Cycle Arrest Leading Strand Elongation Regulation Of Fibroblast Proliferation Senescence-associated Heterochromatin Focus Assembly Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cell Division
Tagcloud ?		atpgammas cmg cmgs congruencies cracked dimeric dissociating dnab duplex engages enters establishes eukaryotes explains gins handed helicase helicases helps hexamers matures mcm mcm2 separates spiral strands subcomplex subpopulation transitions