APC2 and TUBB4A

		APC2	TUBB4A
Description		APC regulator of Wnt signaling pathway 2	tubulin beta 4A class IVa
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Actin Filament Microtubule Cytoskeleton Catenin Complex Midbody Beta-catenin Destruction Complex Leading Edge Membrane Lamellipodium Membrane Filamentous Actin Intercellular Bridge Perinuclear Region Of Cytoplasm Plasma Membrane Bounded Cell Projection	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Axoneme Microtubule Cytoskeleton Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Intercellular Bridge Extracellular Exosome Mitotic Spindle
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding Gamma-catenin Binding	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding GTP Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Cell Fate Specification Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Nervous System Development Wnt Signaling Pathway Cell Migration Negative Regulation Of Wnt Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Activation Of GTPase Activity	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Negative Regulation Of Microtubule Polymerization
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			Epothilone D Patupilone CYT997 ZEN-012 Artenimol
Diseases		Colorectal cancer
GWAS		Lean body mass ( 28552196)	Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403)
Interacting Genes		9 interacting genes: AXIN2 CTNNB1 DSCAM FXR1 MAPRE1 MAPRE3 NLGN3 SMARCA2 YAP1	15 interacting genes: BMPR2 CEBPA CLN8 FNDC3B LINC01554 NEAT1 NR4A1 OGT RBM11 RSPH1 SELENOF STAU1 STK11 SUMO2 YWHAG
Entrez ID		10297	10382
HPRD ID		09802	04045
Ensembl ID		ENSG00000115266	ENSG00000104833
Uniprot IDs		O95996	M0QZL7 M0R1I1 M0R278 P04350
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Development Regulation Of Multicellular Organismal Development Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Nervous System Development Regulation Of Cellular Component Organization Positive Regulation Of Nervous System Development Positive Regulation Of Multicellular Organismal Process Regulation Of Organelle Organization Regulation Of Neurogenesis Mitotic Spindle Astral Microtubule End Positive Regulation Of Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Cell Differentiation Regulation Of Developmental Process Positive Regulation Of Neurogenesis Regulation Of Microtubule Polymerization Neuron To Neuron Synapse Beta-catenin Destruction Complex Regulation Of Nephron Tubule Epithelial Cell Differentiation Cell Projection Membrane Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Microtubule Polymerization Or Depolymerization Dorsal/ventral Axis Specification Negative Regulation Of Microtubule Polymerization Protein Localization To Microtubule Regulation Of Epithelial Cell Differentiation Involved In Kidney Development I-SMAD Binding Regulation Of Sister Chromatid Cohesion Developmental Growth Involved In Morphogenesis Microtubule Plus-end Binding Cell Development Regulation Of Osteoblast Differentiation Protein Serine/threonine Kinase Binding Cellular Component Assembly Microtubule Plus-end Glandular Epithelial Cell Differentiation Regulation Of Microtubule Cytoskeleton Organization Spindle Midzone Lung Epithelial Cell Differentiation Lung Cell Differentiation Germ Cell Development Positive Regulation Of Cellular Component Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Chromosome Organization Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Synapse Organization Positive Regulation Of Stem Cell Population Maintenance	Non-canonical Inflammasome Complex Assembly LncRNA-mediated Post-transcriptional Gene Silencing Cellular Developmental Process
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