APC2 and MAPRE1

Number of citations of the paper that reports this interaction (PMID 10644998)
26

Data Source:
HPRD (in vitro)

		APC2	MAPRE1
Gene Name		adenomatosis polyposis coli 2	microtubule-associated protein, RP/EB family, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytoplasmic Microtubule Actin Filament Microtubule Cytoskeleton Catenin Complex Lamellipodium Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Microtubule Cytoplasmic Microtubule Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding	Protein Binding Protein C-terminus Binding Poly(A) RNA Binding Microtubule Plus-end Binding
	Biological Process	Wnt Signaling Pathway Negative Regulation Of Catenin Import Into Nucleus Negative Regulation Of Canonical Wnt Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Cell Proliferation Negative Regulation Of Microtubule Polymerization Protein Localization To Microtubule Cell Division Positive Regulation Of Microtubule Plus-end Binding
Pathways			Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: AXIN2 CTNNB1 MAPRE1 MAPRE3 UBC	40 interactors: ABCB1 APC APC2 APP AURKB BCL3 CDK5RAP2 CLASP1 CLASP2 CLIP1 COPS5 COPS8 CSN3 CYLD DCTN1 HSPA1A IKBKG KAT2B KAT5 KIF2C LMO2 LRP1 MACF1 MAPRE2 MAPRE3 NAV1 NUPR1 PDE4DIP PIK3R4 POLE2 PQBP1 PSMA1 SPDYE2 STK11 TERF1 TRAF2 TRIO TROAP TUBA1A TUBB
Entrez ID		10297	22919
HPRD ID		09802	04379
Ensembl ID		ENSG00000115266	ENSG00000101367
Uniprot IDs		O95996	B4DM33 Q15691
PDB IDs			1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3TQ7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Microtubule Plus-end Binding Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Sister Chromatid Cohesion Positive Regulation Of Wnt Signaling Pathway Dorsal/ventral Axis Specification Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Wnt Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Organ Formation Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Stem Cell Differentiation Cell Cycle Regulation Of Epithelial To Mesenchymal Transition Regulation Of Phosphorus Metabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Protein Binding Regulation Of Cell Cycle Process Regulation Of Chromosome Segregation Positive Regulation Of Type I Interferon Production Regulation Of Cartilage Development Positive Regulation Of Cell Death Regulation Of Type I Interferon Production Regulation Of Chondrocyte Development Axis Specification Mitotic Cell Cycle Process Regulation Of Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Dorsal/ventral Pattern Formation Positive Regulation Of Binding Regulation Of Osteoblast Differentiation Cell Proliferation Positive Regulation Of Protein Phosphorylation Odontogenesis Mitotic Cell Cycle Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mismatch Repair Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus	Cell Cycle Process Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Regulation Of Microtubule-based Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Microtubule-based Process Response To Stimulus Organelle Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Complex Assembly Regulation Of Cytoskeleton Organization Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Microtubule Depolymerization Regulation Of Chromosome Segregation Cullin Deneddylation Cellular Localization Regulation Of Wnt Signaling Pathway Establishment Or Maintenance Of Cell Polarity Response To Radiation Protein Deneddylation Negative Regulation Of Microtubule Polymerization Or Depolymerization Cellular Component Assembly Spindle Checkpoint Positive Regulation Of Microtubule Polymerization Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Microtubule Bundle Formation Response To Light Stimulus Cellular Protein Complex Assembly Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Transferase Activity
Tagcloud ?		anaphase attenuation believed binds correlates cyclosome degradation demonstrates dispensable downregulated downregulation e3 implications knock ligase mdm2 oncoprotein polyubiquitination promoting proteasomal proto regulator rnai scaffold senescence shows stabilization ubiquitin	akap450 akap9 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant
Tagcloud (Difference) ?		anaphase attenuation believed binds correlates cyclosome degradation demonstrates dispensable downregulated downregulation e3 implications knock ligase mdm2 oncoprotein polyubiquitination promoting proteasomal proto regulator rnai scaffold senescence shows stabilization ubiquitin	akap450 akap9 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant
Tagcloud (Intersection) ?