APC2 and MAPRE3

Number of citations of the paper that reports this interaction (PMID 10644998)
26

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		APC2	MAPRE3
Gene Name		adenomatosis polyposis coli 2	microtubule-associated protein, RP/EB family, member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytoplasmic Microtubule Actin Filament Microtubule Cytoskeleton Catenin Complex Lamellipodium Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Cytoplasmic Microtubule Microtubule Cytoskeleton Midbody Microtubule Plus-end Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding	Protein Binding Microtubule Binding
	Biological Process	Wnt Signaling Pathway Negative Regulation Of Catenin Import Into Nucleus Negative Regulation Of Canonical Wnt Signaling Pathway	Mitotic Nuclear Division Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of Microtubule Plus-end Binding
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: AXIN2 CTNNB1 MAPRE1 MAPRE3 UBC	16 interactors: APC2 AURKA AURKB CLASP1 EIF4E2 JUN LMO2 MAPRE1 MAPRE2 PSMA1 PSMB1 RAB1A SDCBP SIAH1 TROAP TXN2
Entrez ID		10297	22924
HPRD ID		09802	16156
Ensembl ID		ENSG00000115266	ENSG00000084764
Uniprot IDs		O95996	Q9UPY8
PDB IDs			1WYO 3CO1 3TQ7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Microtubule Plus-end Binding Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Sister Chromatid Cohesion Positive Regulation Of Wnt Signaling Pathway Dorsal/ventral Axis Specification Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Wnt Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Organ Formation Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Stem Cell Differentiation Cell Cycle Regulation Of Epithelial To Mesenchymal Transition Regulation Of Phosphorus Metabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Protein Binding Regulation Of Cell Cycle Process Regulation Of Chromosome Segregation Positive Regulation Of Type I Interferon Production Regulation Of Cartilage Development Positive Regulation Of Cell Death Regulation Of Type I Interferon Production Regulation Of Chondrocyte Development Axis Specification Mitotic Cell Cycle Process Regulation Of Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Dorsal/ventral Pattern Formation Positive Regulation Of Binding Regulation Of Osteoblast Differentiation Cell Proliferation Positive Regulation Of Protein Phosphorylation Odontogenesis Mitotic Cell Cycle Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mismatch Repair Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus	Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle Mitotic Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Mitotic Nuclear Division Cell Cycle Process Regulation Of Microtubule Polymerization Or Depolymerization Cell Division Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Modification-dependent Protein Catabolic Process Cell Cycle Phase Transition Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Microtubule Depolymerization Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Microtubule Cytoskeleton Organization Spindle Stabilization Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule-based Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Cellular Macromolecule Catabolic Process Cellular Protein Localization Cell Cycle Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Regulation Of Binding Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Histone-serine Phosphorylation Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Complex Disassembly Positive Regulation Of Proteolysis Negative Regulation Of Binding Negative Regulation Of Protein Ubiquitination
Tagcloud ?		anaphase attenuation believed binds correlates cyclosome degradation demonstrates dispensable downregulated downregulation e3 implications knock ligase mdm2 oncoprotein polyubiquitination promoting proteasomal proto regulator rnai scaffold senescence shows stabilization ubiquitin
Tagcloud (Difference) ?		anaphase attenuation believed binds correlates cyclosome degradation demonstrates dispensable downregulated downregulation e3 implications knock ligase mdm2 oncoprotein polyubiquitination promoting proteasomal proto regulator rnai scaffold senescence shows stabilization ubiquitin
Tagcloud (Intersection) ?