DLGAP2 and SHANK2

Number of citations of the paper that reports this interaction (PubMedID 10527873)
0

Data Source:
BioGRID (two hybrid)

		DLGAP2	SHANK2
Description		DLG associated protein 2	SH3 and multiple ankyrin repeat domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Neurofilament Plasma Membrane Postsynaptic Density Membrane Synapse Glutamatergic Synapse Postsynaptic Specialization	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding Molecular Adaptor Activity	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Neuron-neuron Synaptic Transmission Signaling Modulation Of Chemical Synaptic Transmission	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Daytime nap ( 33568662) End-stage renal disease ( 29885931) Eye morphology ( 29921221) Femur bone mineral density x serum urate levels interaction ( 34046847) Lung cancer ( 28604730) Menarche (age at onset) ( 23599027) Neuritic plaque ( 31497858) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive astigmatism ( 30306274) Stroke ( 32693751) Tau burden ( 33426524) Triglycerides ( 24886709) White matter microstructure in first episode schizophrenia (right posterior cingulate cortex) ( 28924203)	Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		18 interacting genes: ABI2 ADRB1 CYSRT1 DGCR6 DLG2 DLG4 DLGAP1 GRK5 KRT40 KRTAP4-2 MAGI2 NLGN4X NOS1 SHANK2 SHANK3 SORBS2 TSPOAP1 UBASH3B	21 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		9228	22941
HPRD ID		09258	04479
Ensembl ID		ENSG00000198010	ENSG00000162105
Uniprot IDs		A0A1B0GTN4	A0A590UJ45 A6NHU9 Q9UPX8
PDB IDs			8ATJ 8B10
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Vocalization Behavior Ionotropic Glutamate Receptor Binding Receptor Clustering Synapse Social Behavior Dendritic Spine Scaffold Protein Binding Beta-1 Adrenergic Receptor Binding Synaptic Receptor Adaptor Activity AMPA Glutamate Receptor Clustering Modulation Of Chemical Synaptic Transmission Modulation Of Excitatory Postsynaptic Potential Learning Neuron Projection Cell Projection Synaptic Signaling Neuron Spine Photoreceptor Inner Segment Juxtaparanode Region Of Axon Regulation Of Membrane Potential Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Postsynaptic Membrane Dendritic Spine Morphogenesis Kinase Binding Postsynaptic Density Membrane Learning Or Memory Calyx Of Held Response To Potassium Ion SH3 Domain Binding Cytoskeletal Anchor Activity Regulation Of System Process Regulation Of Nervous System Process Regulation Of Cell Communication Regulation Of Signaling Protein Localization To Membrane Chemical Synaptic Transmission Cognition Regulation Of The Force Of Heart Contraction Regulation Of Long-term Neuronal Synaptic Plasticity Cell-cell Signaling Trans-synaptic Signaling Signaling Excitatory Synapse Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Adult Behavior Cell Communication	Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse
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