MIA2 and SEC24C

Number of citations: 30 (PubMedID 21525241)
Data Source: BioGRID (two hybrid)

		MIA2	SEC24C
Name		MIA SH3 domain ER export factor 2	SEC24 homolog C, COPII component
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Exit Site	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Enzyme Activator Activity Cargo Receptor Activity	SNARE Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Secretion Protein Exit From Endoplasmic Reticulum Vesicle Cargo Loading Lipoprotein Transport Protein Localization To Endoplasmic Reticulum Exit Site	In Utero Embryonic Development Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport COPII-coated Vesicle Cargo Loading
Pathways		Cargo concentration in the ER	Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
GWAS		No GWAS studies recorded	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Crohn's disease ( 28067908 ) Lung function (FEV1) ( 30175238 ) Self-rated health ( 27864402 )
Interacting Genes		15 interacting genes: CCHCR1 CEP57 DGCR6 EMILIN1 GRB2 MAGEB18 PDCD6 PSMA3 RASAL2 RSPH1 SEC23A SEC24C SS18L1 TLE5 TTC23L	10 interacting genes: APP CRYAA FBXO7 MIA2 MIA3 MOS SEC23A SEC23B SPP1 WIPF1
Entrez ID		4253	9632
HPRD ID		03680	06217
Ensembl ID		ENSG00000150527	ENSG00000176986
Uniprot IDs		Q4G155 Q59FD2 Q96PC5	P53992
PDB IDs		Not available	3EH2 6PU1 8CL3
GO Terms Enriched among Interactors		COPII Vesicle Coat Endoplasmic Reticulum Exit Site ER To Golgi Transport Vesicle Membrane Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Cargo Loading Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Developmental Process	Vesicle Cargo Loading Endoplasmic Reticulum Exit Site COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport COPII-coated Vesicle Budding Protein Localization To Endoplasmic Reticulum Exit Site Golgi Vesicle Transport Lipoprotein Transport Protein Localization To Endoplasmic Reticulum COPII Vesicle Coat Establishment Of Localization In Cell Cargo Receptor Activity Vesicle Budding From Membrane Vesicle-mediated Transport Intracellular Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Endoplasmic Reticulum Lumen Establishment Of Protein Localization Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury ER To Golgi Transport Vesicle Membrane Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Lymphocyte Migration Cellular Localization Endoplasmic Reticulum Cytoplasmic Vesicle Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Estradiol Secretion PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Regulation Of Estradiol Secretion Lewy Body Core Response To Norepinephrine