MIA2 and MAGEB18

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MIA2	MAGEB18
Description		MIA SH3 domain ER export factor 2	MAGE family member B18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Exit Site	Nucleus Cytoplasm
	Molecular Function	Protein Binding Enzyme Activator Activity Cargo Receptor Activity	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Secretion Protein Exit From Endoplasmic Reticulum Vesicle Cargo Loading Lipoprotein Transport Protein Localization To Endoplasmic Reticulum Exit Site	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Cargo concentration in the ER
Drugs
Diseases
GWAS			Erectile dysfunction and prostate cancer treatment ( 20932654)
Interacting Genes		15 interacting genes: CCHCR1 CEP57 DGCR6 EMILIN1 GRB2 MAGEB18 PDCD6 PSMA3 RASAL2 RSPH1 SEC23A SEC24C SS18L1 TLE5 TTC23L	8 interacting genes: ATXN1 GABPB1 HTT LNX1 MIA2 TNIP1 TP53 TRIM37
Entrez ID		4253	286514
HPRD ID		03680	06647
Ensembl ID		ENSG00000150527	ENSG00000176774
Uniprot IDs		Q4G155 Q59FD2 Q96PC5	Q96M61
PDB IDs
Enriched GO Terms of Interacting Partners?		COPII Vesicle Coat Endoplasmic Reticulum Exit Site ER To Golgi Transport Vesicle Membrane Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Cargo Loading Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Developmental Process	Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process P53 Binding Cellular Localization Regulation Of Protein Stability Regulation Of Autophagy Of Mitochondrion Identical Protein Binding Establishment Of Localization In Cell Intracellular Transport Regulation Of Mitophagy Regulation Of Glial Cell Proliferation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Aggrephagy Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Lipophagy Learning Positive Regulation Of CAMKK-AMPK Signaling Cascade Central Nervous System Development Intracellular Protein Transport Chromatin Binding Histone H2AK119 Ubiquitin Ligase Activity POZ Domain Binding Regulation Of Gliogenesis Nuclear Matrix Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity
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