AP3B2 and RUFY1

Number of citations of the paper that reports this interaction (PubMedID 23144738)
65

Data Source:
BioGRID (pull down)

		AP3B2	RUFY1
Description		adaptor related protein complex 3 subunit beta 2	RUN and FYVE domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Intracellular Vesicle Presynapse Axon Cytoplasm	Cytoplasm Endosome Cytosol Membrane Nuclear Speck Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function		Protein Binding Zinc Ion Binding Lipid Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity SH2 Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Anterograde Axonal Transport Protein Transport Synaptic Vesicle Coating Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Synaptic Vesicle Endocytosis Anterograde Synaptic Vesicle Transport	Endocytosis Small GTPase-mediated Signal Transduction Protein Transport Regulation Of Endocytosis Endosomal Vesicle Fusion Early Endosome To Golgi Transport
Pathways			Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Schizophrenia ( 28991256) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172)	Daytime sleep phenotypes ( 27126917) Dental caries (decayed and filled deciduous teeth) ( 31533690) Eating disorders ( 22911880) Lung cancer ( 28604730) Monocyte percentage of white cells ( 32888494) TPE interval (resting) ( 32386560)
Interacting Genes		7 interacting genes: ADAP1 AP3S1 ATM CLTC CSNK1A1 ERBB2 RUFY1	20 interacting genes: AP3B2 AP3D1 AP3M1 AP3S1 BMX DYNC1LI1 EPHA3 GIT2 ITSN2 OAS1 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A SNCA TRIM23 TXNDC17 UTP25
Entrez ID		8120	80230
HPRD ID		03699	15282
Ensembl ID		ENSG00000103723	ENSG00000176783
Uniprot IDs		F5GYB0 Q13367	A8K7B1 Q96T51
PDB IDs			2YQM 2YW8
Enriched GO Terms of Interacting Partners?		Intracellular Membrane-bounded Organelle Positive Regulation Of Rho Protein Signal Transduction Spindle Establishment Of RNA Localization To Telomere Autophagosome Assembly Negative Regulation Of TOR Signaling Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of TORC1 Signaling Protein Phosphorylation Regulation Of TORC1 Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Leukocyte Proliferation Autophagosome Organization Negative Regulation Of Mononuclear Cell Proliferation Cytoplasmic Vesicle Positive Regulation Of Telomerase Catalytic Core Complex Assembly Phosphorylation Intracellular Protein Localization Protein Kinase Activity Retrograde Transport, Endosome To Golgi Regulation Of Rho Protein Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction ERBB3:ERBB2 Complex Regulation Of Cellular Component Organization DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Cytosolic Transport RNA Polymerase I Core Binding Vacuole Organization Negative Regulation Of Lymphocyte Activation Positive Regulation Of Autophagy Cellular Response To Nitrosative Stress Regulation Of TOR Signaling Peptidyl-serine Autophosphorylation Signal Transduction Kinase Activity Pre-B Cell Allelic Exclusion Cellular Localization AP-type Membrane Coat Adaptor Complex Synaptic Vesicle Coating Cytoplasmic Vesicle Membrane Negative Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Disassembly Negative Regulation Of Immature T Cell Proliferation In Thymus ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Inositol 1,3,4,5 Tetrakisphosphate Binding Organelle Assembly	Synaptic Vesicle Recycling Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated AP-3 Adaptor Complex Synaptic Vesicle Transport Vesicle-mediated Transport In Synapse Anterograde Synaptic Vesicle Transport Synaptic Vesicle Coating GDP Binding Cytoplasmic Vesicle Membrane Vesicle Cargo Loading Early Endosome Protein Transport Establishment Of Vesicle Localization Anterograde Axonal Transport Vesicle Transport Along Microtubule Establishment Of Localization In Cell Vesicle Localization Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Intracellular Protein Localization Melanosome Assembly G Protein Activity Intracellular Protein Transport Axo-dendritic Transport Cellular Localization GTP Binding Platelet Dense Granule Organization Organelle Transport Along Microtubule Intracellular Transport Membrane Coat Post-Golgi Vesicle-mediated Transport Presynapse Vesicle Coating Organelle Localization Melanosome Organization Establishment Of Organelle Localization Pigment Granule Organization Terminal Bouton Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle Organization GTPase Activity Transport Along Microtubule Receptor-mediated Endocytosis Nucleotide Binding Secretory Granule Organization Microtubule-based Movement
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