AP3B2 and ADAP1

Number of citations of the paper that reports this interaction (PubMedID 12565890)
0

Data Source:
HPRD (in vitro)

		AP3B2	ADAP1
Description		adaptor related protein complex 3 subunit beta 2	ArfGAP with dual PH domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Intracellular Vesicle Presynapse Axon Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function		GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Intracellular Protein Transport Anterograde Axonal Transport Protein Transport Synaptic Vesicle Coating Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Synaptic Vesicle Endocytosis Anterograde Synaptic Vesicle Transport	Cell Surface Receptor Signaling Pathway Regulation Of GTPase Activity
Pathways			Nuclear signaling by ERBB4
Drugs
Diseases
GWAS		Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Schizophrenia ( 28991256) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172)	Apolipoprotein A1 levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		7 interacting genes: ADAP1 AP3S1 ATM CLTC CSNK1A1 ERBB2 RUFY1	24 interacting genes: ANP32A AP3B2 CSNK1A1 DVL3 GADD45A GOLGA2 GSK3B NCL PIK3CA PLEKHF2 PRKCA PRKCE PRKCI PRKCZ PRKD1 PSME3 PURA RANBP9 RPS9 SDCBP2 SF3A3 SRSF2 SUB1 SUPV3L1
Entrez ID		8120	11033
HPRD ID		03699	09733
Ensembl ID		ENSG00000103723	ENSG00000105963
Uniprot IDs		F5GYB0 Q13367	A0A087WTN6 A8K3A2 B4DUZ7 O75689
PDB IDs			3FEH 3FM8 3LJU 3MDB
Enriched GO Terms of Interacting Partners?		Intracellular Membrane-bounded Organelle Positive Regulation Of Rho Protein Signal Transduction Spindle Establishment Of RNA Localization To Telomere Autophagosome Assembly Negative Regulation Of TOR Signaling Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of TORC1 Signaling Protein Phosphorylation Regulation Of TORC1 Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Leukocyte Proliferation Autophagosome Organization Negative Regulation Of Mononuclear Cell Proliferation Cytoplasmic Vesicle Positive Regulation Of Telomerase Catalytic Core Complex Assembly Phosphorylation Intracellular Protein Localization Protein Kinase Activity Retrograde Transport, Endosome To Golgi Regulation Of Rho Protein Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction ERBB3:ERBB2 Complex Regulation Of Cellular Component Organization DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Cytosolic Transport RNA Polymerase I Core Binding Vacuole Organization Negative Regulation Of Lymphocyte Activation Positive Regulation Of Autophagy Cellular Response To Nitrosative Stress Regulation Of TOR Signaling Peptidyl-serine Autophosphorylation Signal Transduction Kinase Activity Pre-B Cell Allelic Exclusion Cellular Localization AP-type Membrane Coat Adaptor Complex Synaptic Vesicle Coating Cytoplasmic Vesicle Membrane Negative Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Disassembly Negative Regulation Of Immature T Cell Proliferation In Thymus ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Inositol 1,3,4,5 Tetrakisphosphate Binding Organelle Assembly	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphorylation Phosphorylation Insulin Receptor Substrate Binding Kinase Activity Intracellular Signal Transduction Protein Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process PAR Polarity Complex Positive Regulation Of Protein Localization Positive Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Response To Peptide Hormone Positive Regulation Of Cellular Component Biogenesis ATP Binding Positive Regulation Of Cell Communication Regulation Of Signal Transduction Nucleus Positive Regulation Of Signaling Regulation Of Apoptotic Process Microtubule-based Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Hormone Stimulus Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Cellular Component Organization Beta-catenin Destruction Complex Response To Phorbol 13-acetate 12-myristate Regulation Of Programmed Cell Death Positive Regulation Of Cell Projection Organization Regulation Of Metabolic Process Regulation Of Autophagy Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Response To Hormone Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Ketone Positive Regulation Of Protein Localization To Membrane Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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