DUSP16 and MAPK8IP2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DUSP16	MAPK8IP2
Description		dual specificity phosphatase 16	mitogen-activated protein kinase 8 interacting protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding Mitogen-activated Protein Kinase Binding Protein Carrier Chaperone	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding
	Biological Process	Signal Transduction Dephosphorylation Negative Regulation Of MAPK Cascade	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Suppression of autophagy Signaling by MAPK mutants
Drugs
Diseases
GWAS		Height ( 31562340) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 30578418)	Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)
Interacting Genes		10 interacting genes: ERBB4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 TRIM54	86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784
Entrez ID		80824	23542
HPRD ID		09525	09674
Ensembl ID		ENSG00000111266	ENSG00000008735
Uniprot IDs		Q9BY84	Q13387
PDB IDs		2VSW 3TG3 4YR8	8RPP
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity MAPK Cascade Cellular Senescence JUN Kinase Activity JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Intracellular Signaling Cassette Protein Kinase Activity Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Protein Phosphorylation Signal Transduction Canonical Inflammasome Complex Assembly Phosphorylation Regulation Of Cardiac Muscle Cell Proliferation ATP Binding Fc Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Heart Growth NLRP1 Inflammasome Complex Assembly Transferase Activity Nucleotide Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway JUN Kinase Binding Regulation Of Organ Growth MAP-kinase Scaffold Activity Response To Light Stimulus Cellular Response To UV-B MAP Kinase Kinase Activity Regulation Of Circadian Rhythm Immune Response-regulating Signaling Pathway Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Response To UV-B ERBB2 Signaling Pathway Response To Radiation Response To UV P38MAPK Cascade Regulation Of Immune Response Mitochondrion Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of MRNA Stability Positive Regulation Of Erythrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Heart Growth Regulation Of RNA Stability	MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade
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