DUSP16 and MAPK11

Number of citations of the paper that reports this interaction (PubMedID 11359773)
0

Data Source:
HPRD (in vitro)

		DUSP16	MAPK11
Description		dual specificity phosphatase 16	mitogen-activated protein kinase 11
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding Mitogen-activated Protein Kinase Binding Protein Carrier Chaperone	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction Dephosphorylation Negative Regulation Of MAPK Cascade	MAPK Cascade Osteoblast Differentiation Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction P38MAPK Cascade Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Protein Maturation Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Bone Development Pyroptotic Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To UV-B Cellular Senescence Cellular Response To Virus NLRP1 Inflammasome Complex Assembly
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Suppression of autophagy Signaling by MAPK mutants	NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Drugs			Minocycline KC706 Regorafenib
Diseases
GWAS		Height ( 31562340) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 30578418)	Acne (severe) ( 24927181) Adult body size ( 32376654)
Interacting Genes		10 interacting genes: ERBB4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 TRIM54	28 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DOT1L DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1
Entrez ID		80824	5600
HPRD ID		09525	04208
Ensembl ID		ENSG00000111266	ENSG00000185386
Uniprot IDs		Q9BY84	Q15759
PDB IDs		2VSW 3TG3 4YR8	3GC8 3GC9 3GP0 8YGW
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity MAPK Cascade Cellular Senescence JUN Kinase Activity JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Intracellular Signaling Cassette Protein Kinase Activity Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Protein Phosphorylation Signal Transduction Canonical Inflammasome Complex Assembly Phosphorylation Regulation Of Cardiac Muscle Cell Proliferation ATP Binding Fc Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Heart Growth NLRP1 Inflammasome Complex Assembly Transferase Activity Nucleotide Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway JUN Kinase Binding Regulation Of Organ Growth MAP-kinase Scaffold Activity Response To Light Stimulus Cellular Response To UV-B MAP Kinase Kinase Activity Regulation Of Circadian Rhythm Immune Response-regulating Signaling Pathway Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Response To UV-B ERBB2 Signaling Pathway Response To Radiation Response To UV P38MAPK Cascade Regulation Of Immune Response Mitochondrion Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of MRNA Stability Positive Regulation Of Erythrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Heart Growth Regulation Of RNA Stability	Intracellular Signal Transduction Mitogen-activated Protein Kinase P38 Binding Regulation Of Growth Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Developmental Growth Chromatin Binding Response To Metal Ion Negative Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Enzyme Binding Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Regulation Of Multicellular Organism Growth Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Response To Stress Mitogen-activated Protein Kinase Binding Regulation Of Developmental Process Chromatin Remodeling Cellular Response To Anisomycin Nucleus Positive Regulation Of RNA Metabolic Process Protein Serine/threonine Phosphatase Activity Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Microglial Cell Activation Response To Anisomycin Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Leukocyte Activation Involved In Inflammatory Response Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Main Axon Liver Development
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