DUSP16

Description		dual specificity phosphatase 16
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding Mitogen-activated Protein Kinase Binding Protein Carrier Chaperone
	Biological Process	Signal Transduction Dephosphorylation Negative Regulation Of MAPK Cascade
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Suppression of autophagy Signaling by MAPK mutants
Drugs
Diseases
GWAS		Height ( 31562340) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 30578418)
Interacting Genes		10 interacting genes: ERBB4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 TRIM54
Entrez ID		80824
HPRD ID		09525
Ensembl ID		ENSG00000111266
Uniprot IDs		Q9BY84
PDB IDs		2VSW 3TG3 4YR8
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity MAPK Cascade Cellular Senescence JUN Kinase Activity JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Intracellular Signaling Cassette Protein Kinase Activity Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Protein Phosphorylation Signal Transduction Canonical Inflammasome Complex Assembly Phosphorylation Regulation Of Cardiac Muscle Cell Proliferation ATP Binding Fc Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Heart Growth NLRP1 Inflammasome Complex Assembly Transferase Activity Nucleotide Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway JUN Kinase Binding Regulation Of Organ Growth MAP-kinase Scaffold Activity Response To Light Stimulus Cellular Response To UV-B MAP Kinase Kinase Activity Regulation Of Circadian Rhythm Immune Response-regulating Signaling Pathway Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Response To UV-B ERBB2 Signaling Pathway Response To Radiation Response To UV P38MAPK Cascade Regulation Of Immune Response Mitochondrion Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of MRNA Stability Positive Regulation Of Erythrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Heart Growth Regulation Of RNA Stability
Tagcloud ?