MFAP5 and FBLN1

Number of citations of the paper that reports this interaction (PMID 12122015)
10

Data Source:
HPRD (two hybrid)

		MFAP5	FBLN1
Gene Name		microfibrillar associated protein 5	fibulin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent	Extracellular Matrix Structural Constituent Calcium Ion Binding Peptidase Activator Activity
	Biological Process	Extracellular Matrix Organization Extracellular Fibril Organization	Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS			Temperament (bipolar disorder) ( 22365631)
Protein-Protein Interactions		4 interactors: FBLN1 FBN1 FBN2 MEGF6	35 interactors: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CTGF ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MFAP5 MOB4 NEDD1 NID1 NOTCH3 NOV PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 VCAN YWHAQ
Entrez ID		8076	2192
HPRD ID		03063	00629
Ensembl ID		ENSG00000197614	ENSG00000077942
Uniprot IDs		B3KW70 Q13361 Q7Z490	P23142 Q8NBH6
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Disassembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Maintenance Of Protein Location Regulation Of Cellular Response To Growth Factor Stimulus Sequestering Of BMP In Extracellular Matrix Bone Trabecula Formation Bone Trabecula Morphogenesis Skeletal System Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Negative Regulation Of BMP Signaling Pathway Trabecula Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Embryo Implantation Negative Regulation Of Signaling Regulation Of BMP Signaling Pathway Positive Regulation Of Ossification Metanephros Development	Extracellular Matrix Organization Extracellular Structure Organization Organ Development Regulation Of Cellular Component Organization System Development Multicellular Organismal Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Morphogenesis Anatomical Structure Development Positive Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Regulation Of Cell Development Cardiovascular System Development Regulation Of Cell Growth Regulation Of Signaling Tissue Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Anatomical Structure Formation Involved In Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Regulation Of Cell Morphogenesis Angiogenesis Positive Regulation Of Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding Blood Vessel Development Vasculature Development Negative Regulation Of Cell Death Central Nervous System Development Regulation Of Protein Metabolic Process DNA-templated Transcription, Initiation Locomotion Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Wound Healing Negative Regulation Of Signal Transduction Blood Vessel Morphogenesis Positive Regulation Of Cell Differentiation Ossification Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		aad aorta assist dcn decorin differentially dissection downregulation eventually fbln1 fbln2 fbn1 fibrillin fibulin immunology interfer marfan medscan microfibrillar pathophysiological piqor qrt quadruplicates served software threatening tm unclarified weaken	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Difference) ?		aad aorta assist dcn decorin differentially dissection downregulation eventually fbln2 fbn1 fibrillin fibulin immunology interfer marfan medscan microfibrillar pathophysiological piqor qrt quadruplicates served software threatening tm unclarified weaken	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Intersection) ?		fbln1