MFAP5 and MEGF6

Number of citations of the paper that reports this interaction (PMID 12122015)
10

Data Source:
HPRD (two hybrid)

		MFAP5	MEGF6
Gene Name		microfibrillar associated protein 5	multiple EGF-like-domains 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region	Cellular_component Extracellular Region
	Molecular Function	Extracellular Matrix Structural Constituent	Calcium Ion Binding Protein Binding
	Biological Process	Extracellular Matrix Organization Extracellular Fibril Organization	Biological_process
Pathways		Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: FBLN1 FBN1 FBN2 MEGF6	7 interactors: ATN1 ATXN7 CACNA1A CRKL EGFR GFI1B MFAP5
Entrez ID		8076	1953
HPRD ID		03063	11973
Ensembl ID		ENSG00000197614
Uniprot IDs		B3KW70 Q13361 Q7Z490	O75095
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Disassembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Maintenance Of Protein Location Regulation Of Cellular Response To Growth Factor Stimulus Sequestering Of BMP In Extracellular Matrix Bone Trabecula Formation Bone Trabecula Morphogenesis Skeletal System Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Negative Regulation Of BMP Signaling Pathway Trabecula Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Embryo Implantation Negative Regulation Of Signaling Regulation Of BMP Signaling Pathway Positive Regulation Of Ossification Metanephros Development	Activation Of MAPKK Activity Alkanesulfonate Metabolic Process Cerebellar Molecular Layer Development Vestibular Nucleus Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Regulation Of Transcription From RNA Polymerase II Promoter Activation Of Phospholipase A2 Activity Gamma-aminobutyric Acid Secretion Positive Regulation Of Phospholipase A2 Activity Regulation Of Acetylcholine Secretion, Neurotransmission Neurotrophin TRK Receptor Signaling Pathway Response To Cobalamin Response To UV-A Rhythmic Synaptic Transmission Negative Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Hydroxyisoflavone Central Nervous System Development Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Chloride Ion Homeostasis Calcium Ion-dependent Exocytosis Of Neurotransmitter System Development Activation Of Protein Kinase Activity Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Signal Transduction By Phosphorylation Positive Regulation Of Catenin Import Into Nucleus Parathyroid Gland Development Negative Regulation Of Hormone Biosynthetic Process Extracellular Fibril Organization Regulation Of Synaptic Transmission Regulation Of Phospholipase A2 Activity Pons Development Maintenance Of Cell Polarity Neurological System Process Regulation Of Superoxide Anion Generation Toxin Metabolic Process Sulfur Compound Metabolic Process Magnesium Ion Homeostasis Cerebellar Purkinje Cell Differentiation Multicellular Organismal Development Protein Localization To Membrane Regulation Of Phosphorylation Regulation Of Metabolic Process
Tagcloud ?		aad aorta assist dcn decorin differentially dissection downregulation eventually fbln1 fbln2 fbn1 fibrillin fibulin immunology interfer marfan medscan microfibrillar pathophysiological piqor qrt quadruplicates served software threatening tm unclarified weaken
Tagcloud (Difference) ?		aad aorta assist dcn decorin differentially dissection downregulation eventually fbln1 fbln2 fbn1 fibrillin fibulin immunology interfer marfan medscan microfibrillar pathophysiological piqor qrt quadruplicates served software threatening tm unclarified weaken
Tagcloud (Intersection) ?