MFAP5 and FBN1

Number of citations of the paper that reports this interaction (PMID 12122015)
10

Data Source:
HPRD (in vivo)

		MFAP5	FBN1
Gene Name		microfibrillar associated protein 5	fibrillin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Extracellular Matrix Organization Extracellular Fibril Organization	Skeletal System Development Metanephros Development Heart Development Extracellular Matrix Disassembly Extracellular Matrix Organization Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Molecules associated with elastic fibres Elastic fibre formation Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Breast cancer ( 17903305) Thoracic aortic aneurysms and dissections ( 21909107)
Protein-Protein Interactions		4 interactors: FBLN1 FBN1 FBN2 MEGF6	13 interactors: ATXN7 CALR DCN ELN FBLN2 FBN2 HSPG2 LTBP1 MFAP2 MFAP5 MYOC SPRY2 VCAN
Entrez ID		8076	2200
HPRD ID		03063	00618
Ensembl ID		ENSG00000197614	ENSG00000166147
Uniprot IDs		B3KW70 Q13361 Q7Z490	P35555
PDB IDs			1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86
Enriched GO Terms of Interacting Partners?		Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Disassembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Maintenance Of Protein Location Regulation Of Cellular Response To Growth Factor Stimulus Sequestering Of BMP In Extracellular Matrix Bone Trabecula Formation Bone Trabecula Morphogenesis Skeletal System Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Negative Regulation Of BMP Signaling Pathway Trabecula Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Embryo Implantation Negative Regulation Of Signaling Regulation Of BMP Signaling Pathway Positive Regulation Of Ossification Metanephros Development	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Glycosaminoglycan Catabolic Process Organ Development Chondroitin Sulfate Metabolic Process Sequestering Of Extracellular Ligand From Receptor Negative Regulation Of Signal Transduction Dermatan Sulfate Biosynthetic Process Negative Regulation Of Signaling Striated Muscle Tissue Development Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Muscle Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Negative Regulation Of Signal Transduction System Development Chondroitin Sulfate Biosynthetic Process Glycoprotein Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Glycosaminoglycan Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Organ Morphogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Multicellular Organismal Development Pathogenesis Skeletal System Development Anatomical Structure Development Proteoglycan Biosynthetic Process Ossification Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Developmental Process Peptide Antigen Assembly With MHC Class I Protein Complex Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sulfur Compound Metabolic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Glycoprotein Biosynthetic Process ERBB2 Signaling Pathway
Tagcloud ?		aad aorta assist dcn decorin differentially dissection downregulation eventually fbln1 fbln2 fbn1 fibrillin fibulin immunology interfer marfan medscan microfibrillar pathophysiological piqor qrt quadruplicates served software threatening tm unclarified weaken	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Difference) ?		aad aorta assist dcn decorin differentially dissection downregulation eventually fbln1 fbln2 fibulin immunology interfer marfan medscan microfibrillar pathophysiological piqor qrt quadruplicates served software threatening tm unclarified weaken	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Intersection) ?		fbn1 fibrillin