MFAP5 and FBN2

Number of citations of the paper that reports this interaction (PMID 12122015)
10

Data Source:
HPRD (two hybrid)

		MFAP5	FBN2
Gene Name		microfibrillar associated protein 5	fibrillin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Extracellular Matrix Organization Extracellular Fibril Organization	Anatomical Structure Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Positive Regulation Of Osteoblast Differentiation Bone Trabecula Formation
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Height ( 21998595) Obesity (extreme) ( 19553259) Temperament ( 22832960)
Protein-Protein Interactions		4 interactors: FBLN1 FBN1 FBN2 MEGF6	7 interactors: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2
Entrez ID		8076	2201
HPRD ID		03063	00416
Ensembl ID		ENSG00000197614	ENSG00000138829
Uniprot IDs		B3KW70 Q13361 Q7Z490	P35556
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Disassembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Maintenance Of Protein Location Regulation Of Cellular Response To Growth Factor Stimulus Sequestering Of BMP In Extracellular Matrix Bone Trabecula Formation Bone Trabecula Morphogenesis Skeletal System Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Negative Regulation Of BMP Signaling Pathway Trabecula Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Embryo Implantation Negative Regulation Of Signaling Regulation Of BMP Signaling Pathway Positive Regulation Of Ossification Metanephros Development	Extracellular Matrix Organization Extracellular Structure Organization Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of BMP Signaling Pathway Dendrite Regeneration Extracellular Matrix Disassembly Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Maintenance Of Protein Location Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Sequestering Of BMP In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway System Development Negative Regulation Of Signal Transduction Anatomical Structure Morphogenesis Extracellular Fibril Organization Kidney Development SMAD Protein Complex Assembly Negative Regulation Of Signaling Renal System Development Paraxial Mesoderm Morphogenesis Stress Fiber Assembly Multicellular Organismal Development Nodal Signaling Pathway Urogenital System Development Anatomical Structure Development Organ Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Platelet Formation Embryonic Foregut Morphogenesis Platelet Morphogenesis Foregut Morphogenesis Regulation Of Activin Receptor Signaling Pathway Paraxial Mesoderm Development Response To Cholesterol Dorsal/ventral Axis Specification
Tagcloud ?		aad aorta assist dcn decorin differentially dissection downregulation eventually fbln1 fbln2 fbn1 fibrillin fibulin immunology interfer marfan medscan microfibrillar pathophysiological piqor qrt quadruplicates served software threatening tm unclarified weaken	aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c dmrta1 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae snps tt2 tt3 tt4 v1
Tagcloud (Difference) ?		aad aorta assist dcn decorin differentially dissection downregulation eventually fbln1 fbln2 fbn1 fibrillin fibulin immunology interfer marfan medscan microfibrillar pathophysiological piqor qrt quadruplicates served software threatening tm unclarified weaken	aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c dmrta1 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae snps tt2 tt3 tt4 v1
Tagcloud (Intersection) ?