YEATS4 and MYCN

Number of citations of the paper that reports this interaction (PMID 22068108)
1

Data Source:
BioGRID (two hybrid)

		YEATS4	MYCN
Gene Name		YEATS domain containing 4	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Nuclear Matrix NuA4 Histone Acetyltransferase Complex	Chromatin Nucleus
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Mitotic Nuclear Division Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated	Cartilage Condensation Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Death Lung Development Embryonic Digit Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Skeletal System Morphogenesis Negative Regulation Of Astrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Height ( 18391951) Response to diuretic therapy ( 18591461)	Pulmonary function (interaction) ( 23284291) Wilms tumor ( 22544364)
Protein-Protein Interactions		14 interactors: CEP162 FRMD4A KDM1A MLLT10 MRGBP MYC MYCN NUMA1 PFDN1 RNF8 SMARCB1 TACC1 TACC2 TFAP2B	12 interactors: CSNK2A1 CSNK2A2 MAX MXD1 NEDD4 NMI PIAS2 SIRT1 SP1 TRIM32 YAF2 YEATS4
Entrez ID		8089	4613
HPRD ID		03666	01278
Ensembl ID		ENSG00000127337	ENSG00000134323
Uniprot IDs		F8W0J4 O95619	P04198 Q53XS5
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Cell Cycle Anatomical Structure Development Positive Regulation Of Stem Cell Proliferation System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Interkinetic Nuclear Migration Chromatin Organization Regulation Of Stem Cell Proliferation Multicellular Organismal Development Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Organ Development Forebrain Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nervous System Development Chromatin Remodeling Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Organization Cell Cycle Process Regulation Of RNA Metabolic Process Cell Differentiation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Mesenchymal Cell Proliferation Nucleus Localization Cell Proliferation In Forebrain Regulation Of Mesenchymal Cell Proliferation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Telencephalon Development Tube Development Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Cellular Creatinine Homeostasis Cellular Urea Homeostasis Cellular Ammonia Homeostasis Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Response To DNA Damage Stimulus ATP-dependent Chromatin Remodeling Brain Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Head Development Positive Regulation Of Cell Proliferation Regulation Of Cell Proliferation	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Catabolic Process Cellular Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Regulation Of Chromosome Organization Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Mitotic Spindle Checkpoint Protein Modification By Small Protein Conjugation Regulation Of Growth Negative Regulation Of Chromosome Segregation Regulation Of Proteolysis Peptidyl-lysine Modification Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Biosynthetic Process Cellular Protein Modification Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		12q13 abrogated amplified attenuation bronchial candidate cisplastin cleavage colony contributing conversely copy define helped identifying impairing implicating inducing integrative matched nsclc oncogene oncogenes overexpressed p21waf1 parp reveal rnai senescence	1p36 cdc2l cdc2l1 cdc2l2 conservative cpg1 cpg2 d1z2 delineated duplicated flanking introns melanomas metalloprotease mmp21 mmp22 neuroblastomas nonconservative organized pitslre polymorphic reiterated span specified translocated ubiquitously untranslated ut vntr
Tagcloud (Difference) ?		12q13 abrogated amplified attenuation bronchial candidate cisplastin cleavage colony contributing conversely copy define helped identifying impairing implicating inducing integrative matched nsclc oncogene oncogenes overexpressed p21waf1 parp reveal rnai senescence	1p36 cdc2l cdc2l1 cdc2l2 conservative cpg1 cpg2 d1z2 delineated duplicated flanking introns melanomas metalloprotease mmp21 mmp22 neuroblastomas nonconservative organized pitslre polymorphic reiterated span specified translocated ubiquitously untranslated ut vntr
Tagcloud (Intersection) ?