CCDC14 and DDX6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC14	DDX6
Description		coiled-coil domain containing 14	DEAD-box helicase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Cilium Microtubule Cytoskeleton Centriolar Satellite Ciliary Basal Body	Heterochromatin P-body Outer Dense Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus
	Molecular Function	Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Domain Specific Binding Cadherin Binding
	Biological Process	Substantia Nigra Development Protein Localization To Centrosome	Spermatogenesis Negative Regulation Of Translation Viral RNA Genome Packaging Stem Cell Population Maintenance Neuron Differentiation P-body Assembly Stress Granule Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation Spermatid Differentiation
Pathways			mRNA decay by 5' to 3' exoribonuclease
Drugs			D-tartaric acid
Diseases
GWAS		Intelligence (MTAG) ( 29326435)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 30929738 31619474 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 19838195 28714469) Systemic sclerosis ( 31672989 24387989) Vitiligo ( 22951725)
Interacting Genes		17 interacting genes: APP CALM1 CEP63 CSNK1D CSNK1E DDX6 KDM1A MAGEA11 MAGEB4 MAPK14 PEX5 PIK3R3 PLAC9 PNKP RNF8 TXLNB UBQLN4	75 interacting genes: BEGAIN BEND7 BIRC7 CALCOCO2 CCDC136 CCDC14 CEBPA CEP70 CEP76 CNKSR3 CNOT1 DDX17 DES DISC1 DNAAF11 EDC3 EFHC2 ENTR1 FCHO1 GOLGA2 GPRASP3 HOOK2 IK IKZF1 INKA1 JAKMIP1 JUP KLC4 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LZTS1 MAGED1 MESD MTUS2 NAB2 NONO PAK5 PDLIM7 PICK1 PNMA5 POU6F2 PRDM16 PRPH RAPGEF3 RBM11 RBM14 REL RO60 RUNDC3A SCYL1 SHMT1 SLAIN1 SORBS3 SPATA6 SRPK2 STAT1 TCF12 TCF4 TLE5 TP53BP2 TRAF2 TRIM27 TRIM37 TRIM54 U2AF2 USH1G VPS52 ZBTB10 ZBTB14 ZBTB43 ZBTB8A ZC2HC1C ZNF24
Entrez ID		64770	1656
HPRD ID		07801	02638
Ensembl ID		ENSG00000175455	ENSG00000110367
Uniprot IDs		J3QT39 Q49A88	B2R858 P26196
PDB IDs			1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S
Enriched GO Terms of Interacting Partners?		Regulation Of Double-strand Break Repair Regulation Of Canonical Wnt Signaling Pathway Response To Radiation DNA Damage Response Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Repair Regulation Of Cellular Response To Stress Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Neuron Maturation Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Spindle Pole Cellular Response To Stress Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of DNA Recombination DNA Repair-dependent Chromatin Remodeling Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Metabolic Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Protein Metabolic Process Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Cytosol Cellular Response To Nerve Growth Factor Stimulus Spindle Microtubule Regulation Of Proteasomal Protein Catabolic Process Concave Side Of Sperm Head Positive Regulation Of Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of DNA Metabolic Process Cellular Response To CAMP	Cytoskeleton Identical Protein Binding Protein Binding Intermediate Filament Cytoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Microtubule Nuclear Speck Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Centriole Replication Transcription Coactivator Activity Intermediate Filament Organization Regulation Of MRNA Processing Regulation Of RNA Metabolic Process Cytosol Negative Regulation Of Centriole Replication Aggresome Tumor Necrosis Factor Receptor Binding Negative Regulation Of Metabolic Process Regulation Of Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of Organelle Organization Regulation Of MRNA Metabolic Process Centrosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament
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