DYNC1LI1 and TRIM71

		DYNC1LI1	TRIM71
Description		dynein cytoplasmic 1 light intermediate chain 1	tripartite motif containing 71
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Plasma Membrane Membrane Dynein Complex Endocytic Vesicle Membrane Secretory Granule Membrane Recycling Endosome Membrane Ficolin-1-rich Granule Membrane	P-body Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding GTP Binding GDP Binding Protein-macromolecule Adaptor Activity Dynein Heavy Chain Binding Molecular Adaptor Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Translation Repressor Activity MiRNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Cytoskeleton Organization Microtubule-based Movement Cell Division Regulation Of Vesicle-mediated Transport Early Endosome To Recycling Endosome Transport Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Neural Tube Closure Fibroblast Growth Factor Receptor Signaling Pathway Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Translation Neural Tube Development Regulatory NcRNA-mediated Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Autoubiquitination Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization Stem Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Low density lipoprotein cholesterol levels ( 33339817)	Appendicular lean mass ( 33097823) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pulmonary function ( 21946350) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		11 interacting genes: BRCA2 CEBPA IKBKG NOP56 NUP85 OGT PGAM2 RAB4A REL RUFY1 SLC25A21-AS1	11 interacting genes: CDKN1A MIR1-1 MIR1-2 MIR100 MIR155 MIR15A MIR18B MIR25 MIR29A MIR29B1 MIRLET7F2
Entrez ID		51143	131405
HPRD ID		10917	19029
Ensembl ID		ENSG00000144635	ENSG00000206557
Uniprot IDs		B3KM42 E9PHI6 Q9Y6G9	Q2Q1W2
PDB IDs		6B9H 6PSD 6PSE	7QRX
Enriched GO Terms of Interacting Partners?			RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Translation Negative Regulation Of Cell Cycle G1/S Phase Transition Extracellular Vesicle Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Circulating Fibrinogen Levels Regulation Of Mitotic Cell Cycle Phase Transition MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Amyloid-beta Formation Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Epithelial Cell Differentiation Regulation Of Gene Expression Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Translation Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Multicellular Organismal Process Regulation Of Amide Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Developmental Growth MRNA Destabilization
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