DOK3 and INPP5D

Number of citations of the paper that reports this interaction (PMID 10733577)
41

Data Source:
HPRD (in vivo, in vitro)

		DOK3	INPP5D
Gene Name		docking protein 3	inositol polyphosphate-5-phosphatase, 145kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane	Cytosol Membrane
	Molecular Function	Insulin Receptor Binding Protein Binding	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Ras Protein Signal Transduction	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration
Pathways			Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Crohn's disease ( 22412388 23128233)
Protein-Protein Interactions		9 interactors: ABL1 CSK FYN INPP5D LCK LYN RBPMS RET TRAF1	40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17
Entrez ID		79930	3635
HPRD ID		16834	09033
Ensembl ID		ENSG00000146094	ENSG00000168918
Uniprot IDs		D6RAM3 Q7L591	Q92835
PDB IDs			2YSX
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Antigen Receptor-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Migration Blood Coagulation Hemostasis Cell Motility Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Protein Autophosphorylation Leukocyte Migration Regulation Of Signaling T Cell Costimulation Regulation Of Body Fluid Levels Wound Healing Regulation Of Cell Adhesion Positive Regulation Of Immune Response Positive Regulation Of Cell Activation Locomotion Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Response To Wounding T Cell Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Regulation Of Lymphocyte Activation Positive Regulation Of Cell Differentiation Regulation Of Cell Death Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification B Cell Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Platelet Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell-cell Adhesion	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide
Tagcloud ?		abrogation adaptor attenuates attenuation btk calcineurin cyclosporine defect deleting dispensable follicular germinal helper immunization inability nonredundant pc pcs pd pdl1 pdl2 plcgamma2 programmed reconstitution rectifies suppresses sustain tfh	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		abrogation adaptor attenuates attenuation btk calcineurin cyclosporine defect deleting dispensable follicular germinal helper immunization inability nonredundant pc pcs pd pdl1 pdl2 plcgamma2 programmed reconstitution rectifies suppresses sustain tfh	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?