DOK3 and PLEKHA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DOK3	PLEKHA3
Description		docking protein 3	pleckstrin homology domain containing A3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Secretory Granule Membrane Ficolin-1-rich Granule Membrane	Golgi Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane Recycling Endosome
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Identical Protein Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi
Pathways		Neutrophil degranulation	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Inflammatory bowel disease ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)
Interacting Genes		31 interacting genes: A1CF ABL1 ANKS1A APPL1 APPL2 COX5B CRK CSK DOK1 DOK2 DOK5 DTX2 FYN GCM2 HOXA1 INPP5D LCK LYN MDFI PLEKHA3 PPIH PRKAB2 RBPMS RET RIN3 SHC3 SHE SPAG8 STAT3 TNS2 TRAF1	8 interacting genes: DOK3 ERRFI1 MORF4L1 MRPL45 MYO15B RNMT SH2B2 TCL1B
Entrez ID		79930	65977
HPRD ID		16834	09688
Ensembl ID		ENSG00000146094	ENSG00000116095
Uniprot IDs		A0A6M4C8X9 D6RAM3 Q7L591	Q9HB20
PDB IDs			2KCJ 2MDX 3RCP
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Protein Tyrosine Kinase Activity Antigen Receptor-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Signal Transduction T Cell Costimulation T Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Hepatocyte Growth Factor Positive Regulation Of Macropinocytosis Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of MAPK Cascade Regulation Of Endocytosis CD8 Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Immune Response Cytosol Positive Regulation Of Lymphocyte Activation Regulation Of Phagocytosis Identical Protein Binding Regulation Of Toll-like Receptor 4 Signaling Pathway Macropinosome Immune Response-activating Signaling Pathway Negative Regulation Of Immune System Process Cytoplasm Regulation Of Cell Migration Regulation Of Vesicle-mediated Transport Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway SH2 Domain Binding Leukocyte Migration Regulation Of Immune System Process Regulation Of Cell Motility Positive Regulation Of Cell Activation Positive Regulation Of Pinocytosis Regulation Of Signal Transduction Regulation Of Locomotion
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