DOK3 and PPIH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DOK3	PPIH
Description		docking protein 3	peptidylprolyl isomerase H
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Secretory Granule Membrane Ficolin-1-rich Granule Membrane	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP
	Molecular Function	Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity Ribonucleoprotein Complex Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing Positive Regulation Of Viral Genome Replication Protein-containing Complex Assembly
Pathways		Neutrophil degranulation	mRNA Splicing - Major Pathway SARS-CoV-1 activates/modulates innate immune responses
Drugs			Proline
Diseases
GWAS		Coronary artery disease ( 29212778) Inflammatory bowel disease ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		31 interacting genes: A1CF ABL1 ANKS1A APPL1 APPL2 COX5B CRK CSK DOK1 DOK2 DOK5 DTX2 FYN GCM2 HOXA1 INPP5D LCK LYN MDFI PLEKHA3 PPIH PRKAB2 RBPMS RET RIN3 SHC3 SHE SPAG8 STAT3 TNS2 TRAF1	14 interacting genes: BAG2 BPIFA1 CEBPA DOK3 LNX1 LNX2 N4BP2L2 NIF3L1 PRPF18 PRPF31 PRPF4 SNU13 UBQLN2 XIAP
Entrez ID		79930	10465
HPRD ID		16834	12084
Ensembl ID		ENSG00000146094	ENSG00000171960
Uniprot IDs		A0A6M4C8X9 D6RAM3 Q7L591	O43447 Q6FH36
PDB IDs			1MZW 1QOI 5O9Z 6AHD 8H6K 8H6L 8QO9 8QZS 8R09 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Protein Tyrosine Kinase Activity Antigen Receptor-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Signal Transduction T Cell Costimulation T Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Hepatocyte Growth Factor Positive Regulation Of Macropinocytosis Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of MAPK Cascade Regulation Of Endocytosis CD8 Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Immune Response Cytosol Positive Regulation Of Lymphocyte Activation Regulation Of Phagocytosis Identical Protein Binding Regulation Of Toll-like Receptor 4 Signaling Pathway Macropinosome Immune Response-activating Signaling Pathway Negative Regulation Of Immune System Process Cytoplasm Regulation Of Cell Migration Regulation Of Vesicle-mediated Transport Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway SH2 Domain Binding Leukocyte Migration Regulation Of Immune System Process Regulation Of Cell Motility Positive Regulation Of Cell Activation Positive Regulation Of Pinocytosis Regulation Of Signal Transduction Regulation Of Locomotion	U4/U6 X U5 Tri-snRNP Complex U4 SnRNA Binding U4atac SnRNP U4atac SnRNA Binding U2-type Precatalytic Spliceosome Spliceosomal Complex Identical Protein Binding Regulation Of Hematopoietic Stem Cell Proliferation Precatalytic Spliceosome Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Splicing Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process MRNA Splicing, Via Spliceosome MRNA Processing Protein-RNA Complex Assembly Box C/D Sno(s)RNA Binding RNA Splicing, Via Transesterification Reactions U2-type Post-spliceosomal Complex Histone H3K36me2/H3K36me3 Demethylase Activity Ribonucleoprotein Complex Localization Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Ubiquitin-protein Transferase Activity Response To Vitamin B2 C/EBP Complex Dense Fibrillar Component Generation Of Catalytic Spliceosome For Second Transesterification Step Cajal Body Negative Regulation Of G Protein-coupled Receptor Internalization Immune Response In Nasopharyngeal-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism MRNA Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Regulation Of Stem Cell Proliferation U4/U6 SnRNP Dendritic Microtubule SnRNP Binding PDZ Domain Binding White Fat Cell Proliferation Spliceosomal SnRNP Complex Histone H3K9me2/H3K9me3 Demethylase Activity Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Clathrin-dependent Endocytosis Immune Response In Gut-associated Lymphoid Tissue Regulation Of Protein Catabolic Process
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