PRR5L and RPTOR

Number of citations of the paper that reports this interaction (PMID 18030348)
59

Data Source:
BioGRID (enzymatic study)

		PRR5L	RPTOR
Gene Name		proline rich 5 like	regulatory associated protein of MTOR, complex 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion TORC2 Complex	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Dendrite TORC1 Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin Protein Ligase Binding	RNA Polymerase III Type 1 Promoter DNA Binding RNA Polymerase III Type 2 Promoter DNA Binding RNA Polymerase III Type 3 Promoter DNA Binding TFIIIC-class Transcription Factor Binding Protein Binding Protein Kinase Binding Protein Complex Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling TORC2 Signaling	Positive Regulation Of Endothelial Cell Proliferation Cell Cycle Arrest Insulin Receptor Signaling Pathway Regulation Of Cell Size Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Heat Positive Regulation Of Transcription From RNA Polymerase III Promoter Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways			IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R HSF1-dependent transactivation Release of eIF4E Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Release of eIF4E Cellular response to heat stress S6K1-mediated signalling mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS			Obesity ( 23563607)
Protein-Protein Interactions		4 interactors: MAPKAP1 MLST8 MTOR RPTOR	20 interactors: AKT1S1 EIF4EBP1 ICK IRS1 IRS2 MAPK1 MAPK3 MARK4 MLST8 MTOR PLD2 PRKAA1 PRKAA2 PRR5L RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB
Entrez ID		79899	57521
HPRD ID		07854	06184
Ensembl ID		ENSG00000135362	ENSG00000141564
Uniprot IDs		B3KNU3 Q6MZQ0	F5H7J5 Q6DKI0 Q8N122
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Heat Cellular Response To Heat T Cell Costimulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Heat Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Transcription From RNA Polymerase III Promoter Insulin Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Temperature Stimulus Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Rac GTPase Activity TOR Signaling Positive Regulation Of Cell-cell Adhesion Positive Regulation Of TOR Signaling Regulation Of Transcription From RNA Polymerase III Promoter Fc Receptor Signaling Pathway Response To Insulin Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Component Size Cellular Response To Peptide Regulation Of Rac Protein Signal Transduction Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Response To Peptide Hormone Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cellular Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Response To Peptide Regulation Of TOR Signaling Positive Regulation Of Endothelial Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus	Cellular Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Response To Peptide Hormone Enzyme Linked Receptor Protein Signaling Pathway Regulation Of TOR Signaling Response To Peptide Neurotrophin Signaling Pathway Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cell Communication Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Response To Heat Response To Hormone Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Temperature Stimulus Response To Fibroblast Growth Factor Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Heat Fc-epsilon Receptor Signaling Pathway Response To Stimulus TOR Signaling Signaling Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Cellular Response To Heat Positive Regulation Of TOR Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Tagcloud ?		autophosphorylation cae45978 controller cycloheximide dissociated dissociates flj14213 hyperactivation hyperactive hypothetical knock knocked mtor mtorc1 mtorc2 multiprotein pras40 proline q6mzq0 raptor rictor sin1 structurally tor torc1 torc2 tsc1 tuberous	ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Difference) ?		autophosphorylation cae45978 controller cycloheximide dissociated dissociates flj14213 hyperactivation hyperactive hypothetical knock knocked multiprotein pras40 proline q6mzq0 sin1 structurally tor torc1 torc2	ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant sclerosis
Tagcloud (Intersection) ?		mtor mtorc1 mtorc2 raptor rictor tsc1 tuberous