PRR5L and MLST8

Number of citations of the paper that reports this interaction (PMID 18030348)
59

Data Source:
BioGRID (enzymatic study)

		PRR5L	MLST8
Gene Name		proline rich 5 like	MTOR associated protein, LST8 homolog (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion TORC2 Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin Protein Ligase Binding	Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling TORC2 Signaling	Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Positive Regulation Of TOR Signaling Regulation Of Rac GTPase Activity Regulation Of Actin Cytoskeleton Organization Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Response To Heat
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease mTOR signalling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PKB-mediated events PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling S6K1-mediated signalling mTORC1-mediated signalling Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling mTOR signalling S6K1-mediated signalling mTORC1-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway HSF1-dependent transactivation IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Release of eIF4E VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Cellular response to heat stress Release of eIF4E Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: MAPKAP1 MLST8 MTOR RPTOR	9 interactors: A2M AKT1S1 ATXN1 EIF4EBP1 MTOR PRMT1 PRR5L RPS6KB1 RPTOR
Entrez ID		79899	64223
HPRD ID		07854	17031
Ensembl ID		ENSG00000135362	ENSG00000167965
Uniprot IDs		B3KNU3 Q6MZQ0	Q9BVC4
PDB IDs			4JSN 4JSP 4JSV 4JSX 4JT5 4JT6
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Heat Cellular Response To Heat T Cell Costimulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Heat Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Transcription From RNA Polymerase III Promoter Insulin Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Temperature Stimulus Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Rac GTPase Activity TOR Signaling Positive Regulation Of Cell-cell Adhesion Positive Regulation Of TOR Signaling Regulation Of Transcription From RNA Polymerase III Promoter Fc Receptor Signaling Pathway Response To Insulin Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Component Size Cellular Response To Peptide Regulation Of Rac Protein Signal Transduction Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Response To Peptide Hormone Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cellular Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Response To Peptide Regulation Of TOR Signaling Positive Regulation Of Endothelial Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus	TOR Signaling Response To Heat Regulation Of Cellular Response To Heat Insulin Receptor Signaling Pathway Response To Temperature Stimulus Intracellular Signal Transduction Cellular Response To Insulin Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Heat Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Response To Insulin Cell Communication Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Transcription From RNA Polymerase III Promoter Enzyme Linked Receptor Protein Signaling Pathway Response To Amino Acid Regulation Of Signal Transduction Negative Regulation Of Cell Size Regulation Of Cell Size Response To Peptide Hormone Phosphatidylinositol-mediated Signaling Cellular Response To Organonitrogen Compound Regulation Of Signaling Response To Peptide Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Phosphorylation Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Translation Negative Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cellular Component Size Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Regulation Of TOR Signaling Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Stimulus Response To Hormone Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Regulation Of Translational Initiation Positive Regulation Of Translation
Tagcloud ?		autophosphorylation cae45978 controller cycloheximide dissociated dissociates flj14213 hyperactivation hyperactive hypothetical knock knocked mtor mtorc1 mtorc2 multiprotein pras40 proline q6mzq0 raptor rictor sin1 structurally tor torc1 torc2 tsc1 tuberous	activates akt believed deactivated deregulates drosophila evaluates existence explained gbetal interacting ischemic lies msin1 mtor mtorc1 mtorc2 multiprotein pras40 protor raptor representing rictor s6k1 ser473 stream suppresses threonine tsc2
Tagcloud (Difference) ?		autophosphorylation cae45978 controller cycloheximide dissociated dissociates flj14213 hyperactivation hyperactive hypothetical knock knocked proline q6mzq0 sin1 structurally tor torc1 torc2 tsc1 tuberous	activates akt believed deactivated deregulates drosophila evaluates existence explained gbetal interacting ischemic lies msin1 protor representing s6k1 ser473 stream suppresses threonine tsc2
Tagcloud (Intersection) ?		mtor mtorc1 mtorc2 multiprotein pras40 raptor rictor