PRR5L and MAPKAP1

Number of citations of the paper that reports this interaction (PMID 18030348)
59

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		PRR5L	MAPKAP1
Gene Name		proline rich 5 like	mitogen-activated protein kinase associated protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion TORC2 Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Ubiquitin Protein Ligase Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Ras GTPase Binding Protein Kinase Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling TORC2 Signaling	Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Substantia Nigra Development T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: MAPKAP1 MLST8 MTOR RPTOR	8 interactors: ABCB1 AKT1S1 CDC42EP1 ECI1 EIF4EBP1 MAPK8 PRR5L YWHAG
Entrez ID		79899	79109
HPRD ID		07854	17464
Ensembl ID		ENSG00000135362	ENSG00000119487
Uniprot IDs		B3KNU3 Q6MZQ0	Q9BPZ7
PDB IDs			3VOQ
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Heat Cellular Response To Heat T Cell Costimulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Heat Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Transcription From RNA Polymerase III Promoter Insulin Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Temperature Stimulus Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Rac GTPase Activity TOR Signaling Positive Regulation Of Cell-cell Adhesion Positive Regulation Of TOR Signaling Regulation Of Transcription From RNA Polymerase III Promoter Fc Receptor Signaling Pathway Response To Insulin Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Component Size Cellular Response To Peptide Regulation Of Rac Protein Signal Transduction Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Response To Peptide Hormone Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cellular Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Response To Peptide Regulation Of TOR Signaling Positive Regulation Of Endothelial Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus	Intracellular Signal Transduction TOR Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Mitochondrion Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Regulation Of Protein Metabolic Process Regulation Of Mitochondrion Organization TORC2 Signaling G2/M Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mitotic Cell Cycle Process Regulation Of Signaling Mitotic Cell Cycle IRES-dependent Translational Initiation Cap-independent Translational Initiation JUN Phosphorylation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Xenobiotic Transport Positive Regulation Of Deacetylase Activity Cellular Response To Organic Substance Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Protein Kinase Activity Regulation Of Cellular Component Organization Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Kinase Activity Positive Regulation Of Intracellular Transport Regulation Of Organelle Organization Signaling Negative Regulation Of Cellular Metabolic Process Response To Stimulus Cytoplasmic Translational Initiation Fc Receptor Signaling Pathway Cell Communication Cell Cycle Process
Tagcloud ?		autophosphorylation cae45978 controller cycloheximide dissociated dissociates flj14213 hyperactivation hyperactive hypothetical knock knocked mtor mtorc1 mtorc2 multiprotein pras40 proline q6mzq0 raptor rictor sin1 structurally tor torc1 torc2 tsc1 tuberous
Tagcloud (Difference) ?		autophosphorylation cae45978 controller cycloheximide dissociated dissociates flj14213 hyperactivation hyperactive hypothetical knock knocked mtor mtorc1 mtorc2 multiprotein pras40 proline q6mzq0 raptor rictor sin1 structurally tor torc1 torc2 tsc1 tuberous
Tagcloud (Intersection) ?