MAFK and NFE2L2

Number of citations of the paper that reports this interaction (PMID 10747902)
57

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MAFK	NFE2L2
Gene Name		v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K	nuclear factor, erythroid 2-like 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Cofactor Binding Sequence-specific DNA Binding Transcription Factor Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Cofactor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nervous System Development Blood Coagulation	Transcription From RNA Polymerase II Promoter Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Embryonic Development Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: BACH1 BACH2 HIF1A HOXD12 KAT6A MARS NFE2 NFE2L1 NFE2L2 NFE2L3	35 interactors: ATF4 BPTF CASP1 CASP3 CHD6 COPS7A CREB3 CREBBP DYT10 EIF2AK3 GSK3B JUN JUND KEAP1 KPNA3 MAFF MAFG MAFK MAPK7 NCOR2 NFE2 NFE2L3 PMF1 PPARG PRKCA PRKCD PRKCG PRKCH PRKCQ RBMX SUMO1 TNNT1 TRIM24 UBE2E2 WAC
Entrez ID		7975	4780
HPRD ID		02561	02732
Ensembl ID		ENSG00000198517	ENSG00000116044
Uniprot IDs		A4D214 O60675	Q16236
PDB IDs			2FLU 2LZ1 3ZGC
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Cell Death Embryonic Hemopoiesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Regulation Of Cellular Response To Oxidative Stress Cellular Response To Stress Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Bone Mineralization Regulation Of Transcription Involved In G2/M Transition Of Mitotic Cell Cycle Neural Fold Elevation Formation Negative Regulation Of Ossification Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Oxidative Stress Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Response To Stress Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Regulation Of Metabolic Process Transcription, DNA-templated Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Response To Stimulus Transcription From RNA Polymerase II Promoter Response To Wounding Cellular Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Blood Coagulation Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Hemostasis Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Innate Immune Response Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Stimulus Regulation Of Cellular Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hydrolase Activity
Tagcloud ?		abolishment antisense augmented clarify derivative e2 evi gata gel glycoprotein gp ib incubation indolocarbasole k252a meg megakaryoblastic megakaryocyte megakaryocytic mpl oligomers p45 polyploidization prominant shift tal thrombopoietin tpo unclarified	adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators pn proneural psychoactive redox regrowth renewal reprogramming resist ros slc7a11 solute sox2 taqman therapeutics xc xct
Tagcloud (Difference) ?		abolishment antisense augmented clarify derivative e2 evi gata gel glycoprotein gp ib incubation indolocarbasole k252a meg megakaryoblastic megakaryocyte megakaryocytic mpl oligomers p45 polyploidization prominant shift tal thrombopoietin tpo unclarified	adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators pn proneural psychoactive redox regrowth renewal reprogramming resist ros slc7a11 solute sox2 taqman therapeutics xc xct
Tagcloud (Intersection) ?