NFE2L2 and CHD6

Number of citations of the paper that reports this interaction (PMID 16314513)
29

Data Source:
HPRD (two hybrid, in vivo)

		NFE2L2	CHD6
Gene Name		nuclear factor, erythroid 2-like 2	chromodomain helicase DNA binding protein 6
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane	Nucleoplasm DNA-directed RNA Polymerase II, Core Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Cofactor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding	Transcription Cofactor Binding DNA Binding Chromatin Binding ATP Binding ATP-dependent Helicase Activity DNA-dependent ATPase Activity
	Biological Process	Transcription From RNA Polymerase II Promoter Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Embryonic Development Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Transcription, DNA-templated Chromatin Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Pathways
Drugs
Diseases
GWAS			Hippocampal atrophy ( 22745009)
Protein-Protein Interactions		35 interactors: ATF4 BPTF CASP1 CASP3 CHD6 COPS7A CREB3 CREBBP DYT10 EIF2AK3 GSK3B JUN JUND KEAP1 KPNA3 MAFF MAFG MAFK MAPK7 NCOR2 NFE2 NFE2L3 PMF1 PPARG PRKCA PRKCD PRKCG PRKCH PRKCQ RBMX SUMO1 TNNT1 TRIM24 UBE2E2 WAC	6 interactors: ARAF ATXN1L HIST3H3 NFE2L2 TOLLIP ZFYVE9
Entrez ID		4780	84181
HPRD ID		02732	13049
Ensembl ID		ENSG00000116044	ENSG00000124177
Uniprot IDs		Q16236	Q8TD26
PDB IDs		2FLU 2LZ1 3ZGC	2EPB
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Response To Stress Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Regulation Of Metabolic Process Transcription, DNA-templated Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Response To Stimulus Transcription From RNA Polymerase II Promoter Response To Wounding Cellular Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Blood Coagulation Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Hemostasis Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Innate Immune Response Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Stimulus Regulation Of Cellular Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hydrolase Activity
Tagcloud ?		adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators pn proneural psychoactive redox regrowth renewal reprogramming resist ros slc7a11 solute sox2 taqman therapeutics xc xct	arid1a ash1l atlas broadly colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta trrap uncertain validating
Tagcloud (Difference) ?		adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators pn proneural psychoactive redox regrowth renewal reprogramming resist ros slc7a11 solute sox2 taqman therapeutics xc xct	arid1a ash1l atlas broadly colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta trrap uncertain validating
Tagcloud (Intersection) ?