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NFE2L2 and CLIC6
Number of citations of the paper that reports this interaction (PubMedID
35914814
)
83
Data Source:
BioGRID
(two hybrid)
NFE2L2
CLIC6
Description
NFE2 like bZIP transcription factor 2
chloride intracellular channel 6
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Mediator Complex
Protein-DNA Complex
Ciliary Basal Body
RNA Polymerase II Transcription Regulator Complex
Cytoplasm
Plasma Membrane
Membrane
Monoatomic Ion Channel Complex
Chloride Channel Complex
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Molecular Condensate Scaffold Activity
Chloride Channel Activity
Oxidoreductase Activity
D2 Dopamine Receptor Binding
D3 Dopamine Receptor Binding
D4 Dopamine Receptor Binding
Biological Process
Response To Ischemia
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Response To Oxidative Stress
Response To Xenobiotic Stimulus
Gene Expression
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Innate Immune Response
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of D-glucose Import
Cellular Response To Methionine
Response To Caloric Restriction
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Reactive Oxygen Species Metabolic Process
Negative Regulation Of Ferroptosis
Integrated Stress Response Signaling
Negative Regulation Of Cellular Response To Hypoxia
Regulation Of Cellular Response To Oxidative Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Glutathione Biosynthetic Process
Positive Regulation Of ERAD Pathway
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Monoatomic Ion Transport
Chloride Transport
Monoatomic Ion Transmembrane Transport
Chloride Transmembrane Transport
Pathways
Neddylation
Potential therapeutics for SARS
Regulation of HMOX1 expression and activity
Heme signaling
KEAP1-NFE2L2 pathway
KEAP1-NFE2L2 pathway
Nuclear events mediated by NFE2L2
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
NFE2L2 regulating TCA cycle genes
NFE2L2 regulating inflammation associated genes
NFE2L2 regulating anti-oxidant/detoxification enzymes
NFE2L2 regulates pentose phosphate pathway genes
NFE2L2 regulating tumorigenic genes
NFE2L2 regulating MDR associated enzymes
NFE2L2 regulating ER-stress associated genes
Regulation of NFE2L2 gene expression
Regulation of NFE2L2 gene expression
Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
A body shape index (
34021172
)
Estimated glomerular filtration rate (
30604766
31152163
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Asthma (
31959851
)
Breast cancer (
31757997
)
Epigenetic age acceleration in alcohol use disorder (
31466081
)
Hippocampal volume (
29274321
)
Psoriasis (
25903422
)
Waist-to-hip ratio adjusted for BMI (
28552196
)
Interacting Genes
85 interacting genes:
APEX1
ARFIP2
ARPC2
ATF3
ATF4
ATM
ATR
BPTF
BRPF1
BRPF3
BTRC
CASP1
CASP3
CDH1
CEBPG
CERS2
CFAP299
CHD6
CLIC6
COPS7A
CREB3
CREBBP
CREBL2
CREBZF
DDIT3
EIF2AK3
EIF3J
ELF1
ELF3
ELF4
ELF5
ELK1
ETV1
ETV4
ETV6
FBXW11
FOSB
FOSL2
GSK3B
HNRNPR
IRF2
JUN
JUND
KDM1A
KEAP1
KPNA2
KPNA3
KPNA4
LEF1
MAFF
MAFG
MAFK
MAP2K6
MAPK7
MAPK8
NCOR2
NFAT5
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
REL
RELA
SMAD1
SP140
SPIC
STAT3
SUMO1
SUMO2
TADA2A
TBP
TEF
TIGAR
TNNT1
TRIM24
TRIM41
USP11
USP8
WAC
ZBTB24
ZNF396
27 interacting genes:
ACTB
ALDH5A1
ARG2
ATRX
CLIC4
DRD2
DRD3
DRD4
EEF1A1
FCGR1A
GFPT2
HUWE1
LGI1
MYO1E
NFE2L2
NISCH
OXR1
PGK1
PKM
PPRC1
TAF12
TUBGCP5
UBE4A
ZNF18
ZNF224
ZNF234
ZNF439
Entrez ID
4780
54102
HPRD ID
02732
10836
Ensembl ID
ENSG00000116044
ENSG00000159212
Uniprot IDs
A0A8V8TN14
A0A8V8TPA8
Q16236
Q96NY7
PDB IDs
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
7K28
7K29
7K2A
7K2B
7K2C
7K2D
7K2E
7K2K
7O7B
7X5E
7X5F
7X5G
8EJR
8EJS
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Chromatin
Nucleus
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Gene Expression
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nucleoplasm
RNA Polymerase II Transcription Regulator Complex
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Integrated Stress Response Signaling
Intracellular Signaling Cassette
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Signal Transduction
Transcription Cis-regulatory Region Binding
Transcription By RNA Polymerase II
Cellular Response To Stress
Response To Stress
Chromatin Binding
Transcription Regulator Complex
Cellular Response To Chemical Stress
Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go
Dopamine Neurotransmitter Receptor Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Response To Histamine
Synaptic Transmission, Dopaminergic
Behavioral Response To Cocaine
Regulation Of Neurotransmitter Uptake
Arachidonate Secretion
G Protein-coupled Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Dopamine Binding
Positive Regulation Of Neurotransmitter Uptake
Long-chain Fatty Acid Transport
Negative Regulation Of Synaptic Transmission, Glutamatergic
Adult Behavior
Behavioral Response To Ethanol
Regulation Of Dopamine Receptor Signaling Pathway
Circadian Regulation Of Gene Expression
Negative Regulation Of Cellular Response To Hypoxia
Negative Regulation Of Protein Secretion
Prepulse Inhibition
G Protein-coupled Receptor Internalization
Locomotory Behavior
Regulation Of Amine Transport
Adult Locomotory Behavior
Negative Regulation Of Cytosolic Calcium Ion Concentration
Ubiquitin-ubiquitin Ligase Activity
Response To Morphine
Fatty Acid Transport
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Regulation Of Cellular Response To Oxidative Stress
Canonical Glycolysis
Glycolytic Process Through Glucose-6-phosphate
Glycolytic Process Through Fructose-6-phosphate
Regulation Of Cellular Response To Hypoxia
Regulation Of Dopamine Secretion
Rhythmic Process
Acid Secretion
Secretory Granule Lumen
Glucose Catabolic Process
Regulation Of Transcription By RNA Polymerase II
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Protein Transport
Dopamine Metabolic Process
Ficolin-1-rich Granule Lumen
Regulation Of Response To Oxidative Stress
Response To Amphetamine
Regulation Of Cellular Response To Stress
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