MAFK and BACH1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down), HPRD (two hybrid, in vitro)

		MAFK	BACH1
Name		MAF bZIP transcription factor K	BTB domain and CNC homolog 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Heme Binding Ligand-modulated Transcription Factor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity Nuclear events mediated by NFE2L2 NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity NFE2L2 regulating anti-oxidant/detoxification enzymes
GWAS		Appendicular lean mass ( 33097823 )	Alanine aminotransferase levels ( 33547301 ) Aspartate aminotransferase levels ( 33547301 ) Creatine kinase levels ( 29403010 ) Haemorrhoidal disease ( 33888516 ) Pancreatic cancer ( 22158540 ) Selective IgA deficiency ( 27723758 ) Visceral fat ( 22589738 )
Novel Interactors		None recorded	1 novel interactors: HLCS
Interacting Genes		11 interacting genes: BACH1 BACH2 DNMT3L HIF1A HOXD12 KAT6A MARS1 NFE2 NFE2L1 NFE2L2 NFE2L3	18 interacting genes: ANAPC5 ATF2 BATF2 BRCC3 CFTR DDIT3 DYNLL1 HMMR KIF5A MAFB MAFK NR1D1 PATZ1 RBCK1 RPS27A TCF4 USP7 WAC
Entrez ID		7975	571
HPRD ID		02561	04127
Ensembl ID		ENSG00000198517	ENSG00000156273
Uniprot IDs		O60675	O14867
PDB IDs		Not available	2IHC 8S7D 8UA3 8UA6 8UAH 8UBT 8UBU 8UBV 9GP5 9GR9 9GRA
GO Terms Enriched among Interactors		RNA Polymerase II Transcription Regulator Complex Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Integrated Stress Response Signaling Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Copper Ion DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Copper Ion Positive Regulation Of Metabolic Process Cellular Response To Oxidative Stress Negative Regulation Of Macromolecule Metabolic Process Cell Redox Homeostasis Protein Domain Specific Binding Protein-DNA Complex Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Cellular Response To Chemical Stress Regulation Of Nucleus Organization Positive Regulation Of Glutathione Biosynthetic Process Primary Adaptive Immune Response Involving T Cells And B Cells Regulation Of Body Fluid Levels	RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Integrated Stress Response Signaling Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of DNA-binding Transcription Factor Activity CAMP Response Element Binding Protein Binding Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Leucine Zipper Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Response To Nutrient Levels DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA Damage Checkpoint Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Post-translational Protein Modification Nucleus Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Intracellular Signal Transduction Mononuclear Cell Differentiation Positive Regulation Of RNA Metabolic Process Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II T Cell Differentiation Signal Transduction In Response To DNA Damage Macromolecule Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Leukocyte Differentiation Proteolysis Involved In Protein Catabolic Process Response To Stress Regulation Of Insulin Secretion Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Abducens Nucleus Development Hypoglossal Nucleus Development DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress