MAFK and KAT6A

Number of citations of the paper that reports this interaction (PubMedID 17083329)
54

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MAFK	KAT6A
Description		MAF bZIP transcription factor K	lysine acetyltransferase 6A
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleosome Nucleus Nucleoplasm Nucleolus Cytosol PML Body Nuclear Speck MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Chromatin Organization Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Positive Regulation Of Gene Expression Myeloid Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Developmental Process Chromosome Organization Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Hemopoiesis
Pathways		Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity Nuclear events mediated by NFE2L2 NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Sleep duration ( 30531941)
Interacting Genes		11 interacting genes: BACH1 BACH2 DNMT3L HIF1A HOXD12 KAT6A MARS1 NFE2 NFE2L1 NFE2L2 NFE2L3	18 interacting genes: AKT1 ATN1 ATXN1 CREBBP H3-4 H3-5 H3C1 H3C14 H4C1 H4C16 H4C9 HEMGN MAFK PML RERE RUNX1 SPI1 UBE2U
Entrez ID		7975	7994
HPRD ID		02561	03244
Ensembl ID		ENSG00000198517	ENSG00000083168
Uniprot IDs		O60675	A5PKX7 A5PLL3 Q92794
PDB IDs			1M36 2LN0 2OZU 2RC4 3V43 4LJN 4LK9 4LKA 4LLB 5B75 5B76 5B77 5B78 6LSB 7Y43 8DD5 8H7A 9ARR 9DZN 9FKR
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Integrated Stress Response Signaling Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Copper Ion DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Copper Ion Positive Regulation Of Metabolic Process Cellular Response To Oxidative Stress Negative Regulation Of Macromolecule Metabolic Process Cell Redox Homeostasis Protein Domain Specific Binding Protein-DNA Complex Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Cellular Response To Chemical Stress Regulation Of Nucleus Organization Positive Regulation Of Glutathione Biosynthetic Process Primary Adaptive Immune Response Involving T Cells And B Cells Regulation Of Body Fluid Levels	Structural Constituent Of Chromatin Protein Heterodimerization Activity Nucleosome Nucleoplasm Chromatin Remodeling Nucleosome Assembly Chromatin Organization Nucleosome Organization Protein-DNA Complex Assembly DNA Binding Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Chromosome, Telomeric Region Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Chromosome Regulation Of Megakaryocyte Differentiation Telomere Organization Protein Localization To Chromosome, Centromeric Region Regulation Of Cell Differentiation Regulation Of Cell Development Protein-containing Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Oncogene-induced Cell Senescence Protein Localization To Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Organization Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Hemopoiesis Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Chromatin Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Fibroblast Migration Protein Localization To Chromosome Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Response To Light Stimulus Nuclear Matrix
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