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NFE2L2 and PRKCD
Number of citations of the paper that reports this interaction (PubMedID
12198130
)
0
Data Source:
HPRD
(in vitro)
NFE2L2
PRKCD
Description
NFE2 like bZIP transcription factor 2
protein kinase C delta
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Mediator Complex
Protein-DNA Complex
Ciliary Basal Body
RNA Polymerase II Transcription Regulator Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cell-cell Junction
Endomembrane System
Membrane
Nuclear Matrix
Azurophil Granule Lumen
Endolysosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Molecular Condensate Scaffold Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
Zinc Ion Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Insulin Receptor Substrate Binding
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Response To Ischemia
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Response To Oxidative Stress
Response To Xenobiotic Stimulus
Gene Expression
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Innate Immune Response
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of D-glucose Import
Cellular Response To Methionine
Response To Caloric Restriction
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Reactive Oxygen Species Metabolic Process
Negative Regulation Of Ferroptosis
Integrated Stress Response Signaling
Negative Regulation Of Cellular Response To Hypoxia
Regulation Of Cellular Response To Oxidative Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Glutathione Biosynthetic Process
Positive Regulation Of ERAD Pathway
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Protein Phosphorylation
Apoptotic Process
DNA Damage Response
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Immunoglobulin Mediated Immune Response
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Termination Of Signal Transduction
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Endodeoxyribonuclease Activity
Positive Regulation Of Superoxide Anion Generation
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Response To UV
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
Neutrophil Activation
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Regulation Of MRNA Stability
Post-translational Protein Modification
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Protein Stabilization
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Filopodium Assembly
Cell Chemotaxis
Cellular Response To Hydrogen Peroxide
Protein Kinase C Signaling
Cellular Response To Fatty Acid
Cellular Response To Hydroperoxide
Negative Regulation Of Platelet Aggregation
Cellular Senescence
Phospholipase C/protein Kinase C Signal Transduction
Positive Regulation Of Phospholipid Scramblase Activity
Cellular Response To Angiotensin
Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Glucosylceramide Catabolic Process
Positive Regulation Of Sphingomyelin Catabolic Process
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Neddylation
Potential therapeutics for SARS
Regulation of HMOX1 expression and activity
Heme signaling
KEAP1-NFE2L2 pathway
KEAP1-NFE2L2 pathway
Nuclear events mediated by NFE2L2
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
NFE2L2 regulating TCA cycle genes
NFE2L2 regulating inflammation associated genes
NFE2L2 regulating anti-oxidant/detoxification enzymes
NFE2L2 regulates pentose phosphate pathway genes
NFE2L2 regulating tumorigenic genes
NFE2L2 regulating MDR associated enzymes
NFE2L2 regulating ER-stress associated genes
Regulation of NFE2L2 gene expression
Regulation of NFE2L2 gene expression
Regulation of PD-L1(CD274) transcription
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Interferon gamma signaling
KEAP1-NFE2L2 pathway
Drugs
Tamoxifen
Staurosporine
Dequalinium
13-Acetylphorbol
Ingenol mebutate
Benzoyl peroxide
Fostamatinib
Diseases
GWAS
A body shape index (
34021172
)
Estimated glomerular filtration rate (
30604766
31152163
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
A body shape index (
34021172
)
Bipolar disorder (
21926972
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Ulcerative colitis (
23128233
)
Waist circumference adjusted for body mass index (
28552196
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
85 interacting genes:
APEX1
ARFIP2
ARPC2
ATF3
ATF4
ATM
ATR
BPTF
BRPF1
BRPF3
BTRC
CASP1
CASP3
CDH1
CEBPG
CERS2
CFAP299
CHD6
CLIC6
COPS7A
CREB3
CREBBP
CREBL2
CREBZF
DDIT3
EIF2AK3
EIF3J
ELF1
ELF3
ELF4
ELF5
ELK1
ETV1
ETV4
ETV6
FBXW11
FOSB
FOSL2
GSK3B
HNRNPR
IRF2
JUN
JUND
KDM1A
KEAP1
KPNA2
KPNA3
KPNA4
LEF1
MAFF
MAFG
MAFK
MAP2K6
MAPK7
MAPK8
NCOR2
NFAT5
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
REL
RELA
SMAD1
SP140
SPIC
STAT3
SUMO1
SUMO2
TADA2A
TBP
TEF
TIGAR
TNNT1
TRIM24
TRIM41
USP11
USP8
WAC
ZBTB24
ZNF396
121 interacting genes:
ACTA1
ACTA2
ACTB
ADAM9
ADCY7
ADD1
ADD2
ADRA2A
ADRB2
AFAP1
AKT3
APP
ART3
BDKRB2
C1QBP
CD34
CDCP1
CHAT
CNP
CREBBP
CYTH1
DAB2
DYNC1H1
EEF1A1
EGFR
EIF2S1
ELAVL1
EP300
ESRRA
FLI1
FSCN1
FYN
GABRA1
GAP43
GNA12
GNA13
GNAZ
GRK2
GRM5
GSK3A
H1-1
H1-5
HABP4
HDAC5
HNRNPK
HSP90AA1
HSPA4
IGF1R
IKBKB
IL6ST
INSR
IRS1
ITGA6
ITGB2
ITGB4
ITGB7
ITPR1
KCNJ1
KCNJ4
KLF5
LCK
LMNB1
LMNB2
LYN
MACF1
MAPK1
MAPK3
MAPT
MBP
MEP1B
MS4A2
MUC1
NCF1
NCF4
NFE2L2
NOTCH1
NUMB
OPRD1
PAK1
PDP1
PDP2
PDPK1
PEBP1
PIK3CA
PIK3CB
PLCB1
PLD2
PLSCR1
PLSCR3
PPARA
PPM1A
PPP1CA
PPP2CA
PPP2R5C
PRKCZ
PRKDC
PTK2B
PTOV1
PTPN22
PTPN6
PTPRA
RAC1
RACK1
RAF1
RASGRP3
RIPK4
RUNX2
SDC4
SHC1
SPRY2
SQSTM1
SRC
STAT1
STAT3
TAGLN
TIAM1
TNFRSF1A
VCP
YWHAB
YWHAG
YWHAZ
Entrez ID
4780
5580
HPRD ID
02732
01501
Ensembl ID
ENSG00000116044
ENSG00000163932
Uniprot IDs
A0A8V8TN14
A0A8V8TPA8
Q16236
B4DFV1
Q05655
PDB IDs
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
7K28
7K29
7K2A
7K2B
7K2C
7K2D
7K2E
7K2K
7O7B
7X5E
7X5F
7X5G
8EJR
8EJS
1YRK
2YUU
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Chromatin
Nucleus
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Gene Expression
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nucleoplasm
RNA Polymerase II Transcription Regulator Complex
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Integrated Stress Response Signaling
Intracellular Signaling Cassette
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Signal Transduction
Transcription Cis-regulatory Region Binding
Transcription By RNA Polymerase II
Cellular Response To Stress
Response To Stress
Chromatin Binding
Transcription Regulator Complex
Cellular Response To Chemical Stress
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Plasma Membrane
Regulation Of Cell Communication
Regulation Of Signaling
Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Focal Adhesion
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Developmental Process
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signaling Cassette
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of MAPK Cascade
Positive Regulation Of Cell Migration
Regulation Of Apoptotic Process
Regulation Of Transport
Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Programmed Cell Death
Positive Regulation Of Locomotion
Regulation Of Metabolic Process
Regulation Of Cell Motility
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cellular Component Organization
Regulation Of Locomotion
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of Protein Localization
Positive Regulation Of Developmental Process
Regulation Of Biological Quality
Regulation Of Cell Adhesion
Response To Peptide Hormone
Regulation Of Macromolecule Biosynthetic Process
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