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NFE2L2 and TIGAR
Number of citations of the paper that reports this interaction (PubMedID
35847493
)
51
Data Source:
BioGRID
(pull down)
NFE2L2
TIGAR
Description
NFE2 like bZIP transcription factor 2
TP53 induced glycolysis regulatory phosphatase
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Mediator Complex
Protein-DNA Complex
Ciliary Basal Body
RNA Polymerase II Transcription Regulator Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Molecular Condensate Scaffold Activity
Catalytic Activity
Fructose-2,6-bisphosphate 2-phosphatase Activity
Protein Binding
Hydrolase Activity
Biological Process
Response To Ischemia
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Response To Oxidative Stress
Response To Xenobiotic Stimulus
Gene Expression
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Innate Immune Response
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of D-glucose Import
Cellular Response To Methionine
Response To Caloric Restriction
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Reactive Oxygen Species Metabolic Process
Negative Regulation Of Ferroptosis
Integrated Stress Response Signaling
Negative Regulation Of Cellular Response To Hypoxia
Regulation Of Cellular Response To Oxidative Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Glutathione Biosynthetic Process
Positive Regulation Of ERAD Pathway
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Mitophagy
Response To Ischemia
Fructose 2,6-bisphosphate Metabolic Process
Glycolytic Process
Autophagy
Apoptotic Process
Response To Stress
DNA Damage Response
Response To Xenobiotic Stimulus
Response To Gamma Radiation
Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Glucose Catabolic Process To Lactate Via Pyruvate
Regulation Of Programmed Cell Death
Negative Regulation Of Programmed Cell Death
Regulation Of Pentose-phosphate Shunt
Positive Regulation Of DNA Repair
Negative Regulation Of Glycolytic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Phosphate Metabolic Process
Intestinal Epithelial Cell Development
Cellular Response To Cobalt Ion
Cellular Response To Hypoxia
Reactive Oxygen Species Metabolic Process
Negative Regulation Of Mitophagy
Regulation Of Response To DNA Damage Checkpoint Signaling
Positive Regulation Of Hexokinase Activity
Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Positive Regulation Of Pentose-phosphate Shunt
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Neddylation
Potential therapeutics for SARS
Regulation of HMOX1 expression and activity
Heme signaling
KEAP1-NFE2L2 pathway
KEAP1-NFE2L2 pathway
Nuclear events mediated by NFE2L2
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
NFE2L2 regulating TCA cycle genes
NFE2L2 regulating inflammation associated genes
NFE2L2 regulating anti-oxidant/detoxification enzymes
NFE2L2 regulates pentose phosphate pathway genes
NFE2L2 regulating tumorigenic genes
NFE2L2 regulating MDR associated enzymes
NFE2L2 regulating ER-stress associated genes
Regulation of NFE2L2 gene expression
Regulation of NFE2L2 gene expression
Regulation of PD-L1(CD274) transcription
TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS
A body shape index (
34021172
)
Estimated glomerular filtration rate (
30604766
31152163
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
85 interacting genes:
APEX1
ARFIP2
ARPC2
ATF3
ATF4
ATM
ATR
BPTF
BRPF1
BRPF3
BTRC
CASP1
CASP3
CDH1
CEBPG
CERS2
CFAP299
CHD6
CLIC6
COPS7A
CREB3
CREBBP
CREBL2
CREBZF
DDIT3
EIF2AK3
EIF3J
ELF1
ELF3
ELF4
ELF5
ELK1
ETV1
ETV4
ETV6
FBXW11
FOSB
FOSL2
GSK3B
HNRNPR
IRF2
JUN
JUND
KDM1A
KEAP1
KPNA2
KPNA3
KPNA4
LEF1
MAFF
MAFG
MAFK
MAP2K6
MAPK7
MAPK8
NCOR2
NFAT5
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
REL
RELA
SMAD1
SP140
SPIC
STAT3
SUMO1
SUMO2
TADA2A
TBP
TEF
TIGAR
TNNT1
TRIM24
TRIM41
USP11
USP8
WAC
ZBTB24
ZNF396
3 interacting genes:
APP
NFE2L2
RPL11
Entrez ID
4780
57103
HPRD ID
02732
12610
Ensembl ID
ENSG00000116044
ENSG00000078237
Uniprot IDs
A0A8V8TN14
A0A8V8TPA8
Q16236
Q9NQ88
PDB IDs
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
7K28
7K29
7K2A
7K2B
7K2C
7K2D
7K2E
7K2K
7O7B
7X5E
7X5F
7X5G
8EJR
8EJS
3DCY
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Chromatin
Nucleus
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Gene Expression
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nucleoplasm
RNA Polymerase II Transcription Regulator Complex
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Integrated Stress Response Signaling
Intracellular Signaling Cassette
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Signal Transduction
Transcription Cis-regulatory Region Binding
Transcription By RNA Polymerase II
Cellular Response To Stress
Response To Stress
Chromatin Binding
Transcription Regulator Complex
Cellular Response To Chemical Stress
Response To Copper Ion
Regulation Of Proteolysis
Regulation Of Protein Catabolic Process
Regulation Of Superoxide Metabolic Process
Cellular Response To Copper Ion
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Response To Endoplasmic Reticulum Stress
Amyloid-beta Complex
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Positive Regulation Of Glutathione Biosynthetic Process
Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Proteolysis
Acetylcholine Receptor Activator Activity
PTB Domain Binding
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Positive Regulation Of Gene Expression
Positive Regulation Of Protein Catabolic Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Endosome To Plasma Membrane Transport Vesicle
Positive Regulation Of Endothelin Production
Growth Cone Filopodium
Lipoprotein Particle
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
Cellular Response To Metal Ion
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Glutathione Biosynthetic Process
Aflatoxin Catabolic Process
Response To Norepinephrine
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Protein Metabolic Process
Cellular Response To Norepinephrine Stimulus
Astrocyte Activation Involved In Immune Response
Low-density Lipoprotein Particle Mediated Signaling
Proteasomal Ubiquitin-independent Protein Catabolic Process
Toxin Catabolic Process
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Intermediate-density Lipoprotein Particle
Axon Midline Choice Point Recognition
Positive Regulation Of Amyloid Fibril Formation
Growth Factor Receptor Binding
Main Axon
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Tagcloud (Difference)
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Tagcloud (Intersection)
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