NFE2L2 and ETV6

Number of citations of the paper that reports this interaction (PubMedID 32911434)
54

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NFE2L2	ETV6
Description		NFE2 like bZIP transcription factor 2	ETS variant transcription factor 6
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Mediator Complex Protein-DNA Complex Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleolus Cytosol Plasma Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding
	Biological Process	Response To Ischemia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Response To Oxidative Stress Response To Xenobiotic Stimulus Gene Expression Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Innate Immune Response Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of D-glucose Import Cellular Response To Methionine Response To Caloric Restriction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Reactive Oxygen Species Metabolic Process Negative Regulation Of Ferroptosis Integrated Stress Response Signaling Negative Regulation Of Cellular Response To Hypoxia Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Glutathione Biosynthetic Process Positive Regulation Of ERAD Pathway Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Vitellogenesis Neurogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Proliferation Mesenchymal Cell Apoptotic Process
Pathways		Neddylation Potential therapeutics for SARS Regulation of HMOX1 expression and activity Heme signaling KEAP1-NFE2L2 pathway KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 NFE2L2 regulating TCA cycle genes NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Regulation of PD-L1(CD274) transcription	Signaling by membrane-tethered fusions of PDGFRA or PDGFRB Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		A body shape index ( 34021172) Estimated glomerular filtration rate ( 30604766 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)	Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Asthma ( 27611488) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Colorectal cancer ( 27145994) Height ( 20881960 23563607 25282103 18391951 28552196 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Night sleep phenotypes ( 27126917) Phosphorus levels ( 29403010) Red blood cell count ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		85 interacting genes: APEX1 ARFIP2 ARPC2 ATF3 ATF4 ATM ATR BPTF BRPF1 BRPF3 BTRC CASP1 CASP3 CDH1 CEBPG CERS2 CFAP299 CHD6 CLIC6 COPS7A CREB3 CREBBP CREBL2 CREBZF DDIT3 EIF2AK3 EIF3J ELF1 ELF3 ELF4 ELF5 ELK1 ETV1 ETV4 ETV6 FBXW11 FOSB FOSL2 GSK3B HNRNPR IRF2 JUN JUND KDM1A KEAP1 KPNA2 KPNA3 KPNA4 LEF1 MAFF MAFG MAFK MAP2K6 MAPK7 MAPK8 NCOR2 NFAT5 NFE2 NFE2L3 PAQR4 PMF1 PPARG PRKCA PRKCD RBMX REL RELA SMAD1 SP140 SPIC STAT3 SUMO1 SUMO2 TADA2A TBP TEF TIGAR TNNT1 TRIM24 TRIM41 USP11 USP8 WAC ZBTB24 ZNF396	18 interacting genes: AP1M1 AXIN1 CEBPA CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 NFE2L2 NTAQ1 SIN3A SMURF1 SUMO1 TRAF2 UBE2I
Entrez ID		4780	2120
HPRD ID		02732	15976
Ensembl ID		ENSG00000116044	ENSG00000139083
Uniprot IDs		A0A8V8TN14 A0A8V8TPA8 Q16236	A0A0S2Z3C9 A0A0S2Z3N6 P41212
PDB IDs		2FLU 2LZ1 3ZGC 4IFL 5WFV 6T7V 7K28 7K29 7K2A 7K2B 7K2C 7K2D 7K2E 7K2K 7O7B 7X5E 7X5F 7X5G 8EJR 8EJS	1JI7 1LKY 2DAO 2QAR 2QB0 2QB1 5L0P 7JU2 7N1O 7N2B 7T8J 7TDY 7TW7 7TW8 7TW9 7U4W 7U4Z 8BWU 8E1F 8FRJ 8FRK 8FT6 8FT8 8FZ3 8FZU 8FZV 8THA 9DAM 9DB5 9DOC 9DP8 9DVG 9FEH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Chromatin Nucleus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm RNA Polymerase II Transcription Regulator Complex Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Integrated Stress Response Signaling Intracellular Signaling Cassette Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Transcription By RNA Polymerase II Cellular Response To Stress Response To Stress Chromatin Binding Transcription Regulator Complex Cellular Response To Chemical Stress	Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Regulation Of Immune System Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Immune System Process CD27 Signaling Pathway Small Protein Activating Enzyme Binding Negative Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Protein Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cell Development Cellular Response To Xenobiotic Stimulus Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Enzyme Binding Chromatin Remodeling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Signaling Adaptor Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Targeting To Vacuole Involved In Autophagy Protein Domain Specific Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Macromolecule Catabolic Process Regulation Of Hematopoietic Stem Cell Differentiation I-SMAD Binding Transcription Regulator Complex Regulation Of RNA Metabolic Process Chromatin Cellular Developmental Process Chromatin Binding Proteasomal Protein Catabolic Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Transcription Factor Binding
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