TBC1D17 and RAB5B

Number of citations: 0 (PubMedID 16923123)
Data Source: BioGRID (two hybrid)

		TBC1D17	RAB5B
Name		TBC1 domain family member 17	RAB5B, member RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Autophagosome Cytosol Cytoplasmic Vesicle Recycling Endosome	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Synaptic Vesicle Membrane Early Endosome Membrane Melanosome Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Metal Ion Binding
	Biological Process	Autophagy Protein Transport Retrograde Transport, Endosome To Golgi Regulation Of Cilium Assembly	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Endosomal Transport Antigen Processing And Presentation Regulation Of Endocytosis Plasma Membrane To Endosome Transport
Pathways		TBC/RABGAPs	Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry
GWAS		No GWAS studies recorded	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Anorexia nervosa ( 28494655 ) Aspartate aminotransferase levels ( 33547301 ) Asthma ( 31959851 31619474 30929738 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive function ( 25644384 ) FEV1 ( 30804560 ) Gastroesophageal reflux disease ( 31527586 ) HDL cholesterol levels ( 32203549 ) High density lipoprotein cholesterol levels ( 31928498 ) Lung function (FEV1) ( 30061609 ) Lung function (FEV1/FVC) ( 30804560 ) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401 ) Polycystic ovary syndrome ( 30566500 22885925 ) Refractive error ( 32231278 ) Sum eosinophil basophil counts ( 27863252 ) Type 1 diabetes ( 18198356 ) Vitiligo ( 22951725 )
Novel Interactors		None recorded	1 novel interactors: PRIM1
Interacting Genes		20 interacting genes: ASCC2 CALCOCO1 CCT5 CDKN2D DHX29 FBL GABARAPL1 GPS1 GTF3C1 MAP1LC3A MAP1LC3B NIPSNAP1 OPTN RAB1A RAB5A RAB5B RAB5C SLC1A5 TAX1BP1 UBC	19 interacting genes: APOA5 CDK1 CHM EEA1 FHIP1B GLP1R HUNK PIK3CB RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SNCA SUN2 TBC1D15 TBC1D17 TFRC
Entrez ID		79735	5869
HPRD ID		15471	01544
Ensembl ID		ENSG00000104946	ENSG00000111540
Uniprot IDs		Q9HA65	P61020
PDB IDs		Not available	2HEI
GO Terms Enriched among Interactors		Mitophagy Autophagy Autophagy Of Mitochondrion Autophagosome Melanosome Plasma Membrane To Endosome Transport Cellular Response To Nitrogen Starvation Endomembrane System Phosphatidylethanolamine Binding Macroautophagy G Protein Activity Autophagosome Assembly Autophagosome Organization Autophagosome Maturation Autophagosome Membrane Vacuole Organization Endocytic Vesicle GDP Binding Catabolic Process Extracellular Exosome Cytoplasmic Vesicle Ubiquitin Protein Ligase Binding Phospholipid Binding K63-linked Polyubiquitin Modification-dependent Protein Binding GTPase Activity Early Endosome Import Into Cell Microtubule Protein-containing Complex Disassembly GTP Binding Beta-tubulin Binding U6 SnRNA 2'-O-ribose Methyltransferase Activity Organelle Assembly Organelle Organization Cellular Response To Starvation Organelle Membrane Endosome Endocytosis Early Endosome Membrane Protein-macromolecule Adaptor Activity Response To Nutrient Levels Histone H2AQ104 Methyltransferase Activity JNK Cascade Glutamine Secretion Protein Localization To Phagocytic Vesicle Response To Starvation Cyclin D2-CDK4 Complex Box C/D Sno(s)RNA 3'-end Processing Intracellular Protein Transport Protein Localization To Early Endosome	Vesicle-mediated Transport GTPase Activator Activity Endocytosis Import Into Cell Response To Copper Ion Small GTPase Binding Hsp70 Protein Binding Regulation Of Endocytosis Endocytic Vesicle Endosome Establishment Of Localization In Cell Endosomal Transport Regulation Of Cilium Assembly Intracellular Transport Regulation Of Vesicle-mediated Transport Early Endosome To Late Endosome Transport Regulation Of Receptor-mediated Endocytosis Intracellular Signal Transduction Early Endosome Recycling Endosome Response To Iron Ion Regulation Of Cellular Component Organization Pronuclear Fusion Cellular Localization Glucagon-like Peptide 1 Receptor Activity Ribonucleotide Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mast Cell Chemotaxis Regulation Of Transport